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Protective Effect of Natural Honey, Urtica diocia and Their Mixture against Oxidative Stress Caused by Chronic Ethanol Consumption.

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Last updated: 03 Jan 2025

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Abstract

Background: There is increasing implicating oxidative stress in the pathogenesis of chronic pancreatitis. The aim of this study is to investigate affect alcohol addiction and role of some protecting agent. Material and methods: Forty eight rats (Rattus norvigicus) were divided into 8 groups. Honey (2.5 g /kg b.w), Urtica dioica (250 mg/kg) and Alcohol orally administered at dose (20% exceeds by 2.5% weekly). Results: Ethanol feeding results in increasing serum glucose, total lipids, cholesterol, Low Density Lipoprotein (LDL), triglycerides, urea, liver Glucose-6-Phosphatase (G6Pase), pancreas and liver Malondialdehyde (MDA), Protein Carbonyl (PC). While a decrease were noted in serum insulin, High Density Lipoprotein (HDL), total Protein, Na, K, Ca, Mg, Cu, liver glycogen, pancreas and liver Glucose-6-Phosphate Dehydrogenase (G6PD), Glutathione- S-Transferase (GST), Reduced Glutathione (GSH), Catalase (CAT), Superoxide Dismutase (SOD). Conclusion: Administration of honey, urtica or both with alcohol prevent to great extent the lesions caused by only chronic alcohol administration. Consequently, honey and urtica administration are useful to minimize the hazardous effects resulting from ethanol abuse.

DOI

10.21608/ejhm.2007.17724

Keywords

Alcohol- Antioxidant- Honey, Oxidative Stress

Authors

First Name

G.M.F

Last Name

Edrees

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Mansoura University

Email

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Orcid

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First Name

F.G.

Last Name

EL-Said

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Mansoura University

Email

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City

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Orcid

-

First Name

E.T.

Last Name

Salem.

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Mansoura University.

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-

City

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Orcid

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Volume

27

Article Issue

1

Related Issue

3714

Issue Date

2007-04-01

Receive Date

2018-10-27

Publish Date

2007-04-01

Page Start

223

Page End

233

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 27_Issue 1_Pages 223-233.pdf

PDF . 344.2kB

Link

https://ejhm.journals.ekb.eg/article_17724.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17724

Order

9

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Protective Effect of Natural Honey, Urtica diocia and Their Mixture against Oxidative Stress Caused by Chronic Ethanol Consumption.

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Article

Created At

22 Jan 2023