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17722

Renal Function Reserve in Chronic Obstructive Pulmonary Disease with Type II Respiratory Failure

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Last updated: 24 Dec 2024

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Abstract

Background and objective: increase in renal blood flow in response to certain stimuli such as dopamine infusion, oral protein load, and amino acid infusion. Reduced or absent renal functional reserve (RFR) is an early index of renal impairment. Our work studies the (RFR) in Chronic Obstructive Pulmonary Disease (COPD) patients with chronic compensated type II respiratory failure. Methods: Our study included 15 COPD patients with compensated type II respiratory failure and 5 normal controls. The patient group had mean Pa O2 56.5±6.4 and Pa CO2 56.5±3.2, while in normal controls the mean Pa O2 was 97.4 ± o.3 and Pa CO2 was 42.3 ± 1.2. Hypoxic patients (Pa O2< or =59mm Hg) allowed to receive low flow oxygen by nasal prongs tokeeptheirPaO2 >or=60mmHgandSaO2 >or=90%withoutriseofPaCO2within2 hours before and during the study. The pulsatility index (PI), an index of reno-vascular resistance (RVR), was measured non invasively by Doppler Ultrasonograghy at baseline and 20 minutes after infusion of dopamine in diuretic dose. Results: The baseline PI was nearly similar in the control group and in COPD patients (no significant difference), the PI fell significantly in the control group after dopamine infusion from 1.03 ± 0.14 to 0.83 ± 0.1(P< 0.05), but increased significantly in COPD patients from 1.02 ± 0.12 to1.18 ± 0.13 (P<0.05) after dopamine infusion. Conclusion: Renal functional reserve is impaired in hypercapnic COPD patients and this may be a factor in the development of edema frequently seen in these patients.

DOI

10.21608/ejhm.2007.17722

Authors

First Name

Mahmoud

Last Name

Manal

MiddleName

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Affiliation

Medicine Dept., Faculty of Medicine, Ain Shams University

Email

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City

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Orcid

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First Name

Hassan

Last Name

Shalby

MiddleName

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Affiliation

Medicine Dept., Faculty of Medicine, Ain Shams University

Email

-

City

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Orcid

-

First Name

Nesriene El Margoushy

Last Name

El Margoushy

MiddleName

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Affiliation

Medical and Radiation Research Dept. ,Nuclear Materials Authority

Email

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City

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Orcid

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First Name

Aya M.

Last Name

Abdel Dayem

MiddleName

-

Affiliation

Chest Dept., Faculty of Medicine, Ain Shams University

Email

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City

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Orcid

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Volume

27

Article Issue

1

Related Issue

3714

Issue Date

2007-04-01

Receive Date

2018-10-27

Publish Date

2007-04-01

Page Start

200

Page End

207

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 27_Issue 1_Pages 200-207.pdf

PDF . 299.6kB

Link

https://ejhm.journals.ekb.eg/article_17722.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17722

Order

7

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Renal Function Reserve in Chronic Obstructive Pulmonary Disease with Type II Respiratory Failure

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Article

Created At

22 Jan 2023