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17672

Study on the Oxidant and Antioxidant Status in Vitiligo Patients

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Last updated: 03 Jan 2025

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Abstract

Backgrounds: The aetiology of vitiligo is still unknown. Several hypotheses have been proposed to explain vitiligo: genetic neural, immunological, self destructive, convergence hypothesis and oxidative stress hypothesis The current study is concerned with the oxidative stress hypothesis and how oxidants and antioxidants affect the pathogenesis of vitiligo. So, our aim is to determine the role of malondialdehyde and glutathione in the pathogenesis of vitiligo. The amount of malondialdehyde (oxidant) and glutathione (antioxidant) were measured in serum and in skin tissue in 30 vitiligo cases and 20 healthy controls Results: The study showed significant changes between patients and controls in glutathione level in blood and tissue samples. Also there were significant changes between patients and controls in malondialdehyde glutathione and malondialdehyde play a role  

DOI

10.21608/ejhm.2007.17672

Authors

First Name

Fatma Hassan

Last Name

Shabaka

MiddleName

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Affiliation

Department of Dermatology and Venereology, AI- Azhar University for Girl

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Orcid

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First Name

Sawsan Khalifa

Last Name

EL- Sayed

MiddleName

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Affiliation

Department of Dermatology and Venereology, AI- Azhar University for Girl

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Orcid

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First Name

Gada

Last Name

Abdel- Badea

MiddleName

-

Affiliation

Department of Dermatology and Venereology, AI- Azhar University for Girl

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Orcid

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First Name

Manal Mohsen

Last Name

Mahmoud

MiddleName

-

Affiliation

Prof. of Biochem. Faculty of Medicine Cairo Univ.

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First Name

Rania Mahmoud

Last Name

Hossni

MiddleName

-

Affiliation

M.B., B. ch.

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Volume

28

Article Issue

1

Related Issue

3713

Issue Date

2007-07-01

Receive Date

2018-10-26

Publish Date

2007-07-01

Page Start

429

Page End

438

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 28_Issue 1_Pages 429-438.pdf

PDF . 352.7kB

Link

https://ejhm.journals.ekb.eg/article_17672.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17672

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11

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Study on the Oxidant and Antioxidant Status in Vitiligo Patients

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Article

Created At

22 Jan 2023