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Hypoglycemic Effet Of Some Fluoroquinolones On Normal And Diabetic Experimental Animals

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Last updated: 03 Jan 2025

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Abstract

Background:Fluoroquinolones are among the anti-microbial that have widespread use for treatment of community- and hospital-acquired infections. Although uncommon, hypoglycemia has been reported with some fluoroquinolones and appears to occur most frequently in elderly patients with type 2 diabetes mellitus who were receiving therapy with oral hypoglycemics. The clinical data emerged suggest that the fluoroquinolones can affect glucose homeostasis through an unknown mechanism. The present work aimed to explore the potential effects of some fluoroquinolones on glucose metabolism and blood glucose level in experimental animals. Two fluoroquinolones (gatifloxacin, moxifloxacin) were used in the present study using different rabbit groups; normal and experimentally diabetic. Dug interaction with anti-diabetic drugs was also investigated. Safety considerations were our goal. Materials And Method: In the present work, alloxan (100 mg / kg body weight 3 successive doses, intraperitonially) was used to induce diabetes in experimental animals. The blood glucose level after alloxan was measured. Oral anti-diabetics glimepiride, rosiglitazone, and metformin produced significant lowering effect on blood glucose level in normal and diabetic animals. Gatifloxacin and moxifloxacin were similar in producing lowering of blood glucose level in non diabetic and diabetic animals and significantly potentiated the hypoglycemic action of oral anti-diabetics in the alloxan diabetic rabbits.  

DOI

10.21608/ejhm.2007.17670

Keywords

Oral anti-diabetics Glimepiride, Rosiglitazone, Metformin, Fluoroquinolones (Gatifloxacin and Moxifloxacin) Alloxan and diabetes mellitus

Authors

First Name

Amr Heshmat

Last Name

Rostom

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Affiliation

Department Pharmacology College of Medicine, Al Hasa, King Faisal University.

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First Name

Ali Ibrahim

Last Name

Al-Sultan

MiddleName

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Affiliation

Department Internal Medicine. College of Medicine, Al Hasa, King Faisal University.

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Volume

28

Article Issue

1

Related Issue

3713

Issue Date

2007-07-01

Receive Date

2018-10-26

Publish Date

2007-07-01

Page Start

404

Page End

417

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 28_Issue 1_Pages 404-417.pdf

PDF . 392.4kB

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https://ejhm.journals.ekb.eg/article_17670.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17670

Order

9

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Hypoglycemic Effet Of Some Fluoroquinolones On Normal And Diabetic Experimental Animals

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Article

Created At

22 Jan 2023