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17669

Alteration of Oxidative Status in Rats Following Administration of Acrylamide

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Last updated: 03 Jan 2025

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Abstract

Introduction: Acrylamide (ACR) is a known industrial neurotoxic and carcinogenic chemical in rodents. The recent discovery of acrylamide in wide variety of commonly consumed foods has energized research efforts worldwide to define toxic mechanisms. Objective: The present study is carried out to investigate the effect of acrylamide administration on in vivo malondialdehyde (MDA, a product of lipid peroxidation), reduced glutathione (GSH) as well as copper and zinc superoxide dismutase enzyme activity (Cu/Zn SOD) of rats. Material and Methods: Fourteen adult male Sprague Dawley rats were divided into two groups each containing "7" rats. Group 1 served as negative control fed on basal diet and group 2 (positive control) received basal diet and acrylamide (0.34g/ kg diet) for 11 days. Levels of MDA, GSH and activity of SOD were determined in liver, kidneys, brain, heart, testes, spleen and lungs of rats. Results: ACR treatment significantly increased MDA in all organs; the highest increase was detected in testis (87.9%) and heart (71.5%) while the lowest one was found in kidneys (28.2%). On the other hand, GSH levels and SOD activities were significantly reduced in ACR treated rats. However, the reduction of GSH level ranged from 10.2% to 36.5 %.The inhibition of SOD activities were higher in testis (57.3%) and lungs (38.5%). Conclusion: The present study showed that ACR exerts deteriorated effects on oxidative status of rats.  

DOI

10.21608/ejhm.2007.17669

Keywords

Acrylamide –In vivo- Rats- Tissues – Lipid peroxidation – Reduced glutathione- Superoxide dismutase

Authors

First Name

Hanaa H.

Last Name

El-Sayed

MiddleName

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Affiliation

National Nutrition Institute

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City

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Orcid

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First Name

Shawkia S.

Last Name

Abd El- Halim

MiddleName

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Affiliation

National Nutrition Institute

Email

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City

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Orcid

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First Name

Gehan M.

Last Name

Morsy

MiddleName

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Affiliation

Women's college- Ain Shams University

Email

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City

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Orcid

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First Name

Ayman El-Sayed

Last Name

El- Adawi

MiddleName

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Affiliation

Home Economics college- Minufiya University

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Orcid

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Volume

28

Article Issue

1

Related Issue

3713

Issue Date

2007-07-01

Receive Date

2018-10-26

Publish Date

2007-07-01

Page Start

397

Page End

403

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 28_Issue 1_Pages 397-403.pdf

PDF . 239.5kB

Link

https://ejhm.journals.ekb.eg/article_17669.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17669

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8

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Alteration of Oxidative Status in Rats Following Administration of Acrylamide

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Article

Created At

22 Jan 2023