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17666

The effect of L-Carnitine on Sodium Valproate-Induced Physiological Disturbances in Rats

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Last updated: 24 Dec 2024

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Abstract

Background: Chronic treatment with sodium valproate (VPA) can lead to elevation of specific oxidative metabolites that associated with the drug's toxicity. Results: Valproate exposure leads to an increase in reactive oxygen species (ROS). The levels of lipid peroxidation (malondialdehyde), and lipid profile variables (cholesterol, phospholipids, triglycerides and free fatty acids) were significantly increased (p<0.001) in orally administrated rats with sodium valproate at 400 mg/kg body weight/day. Also the deflection in the activities of catalase (CAT), lactate dehydrogenase (LDH) and Na,K-ATPase was registered where CAT, LDH and Na-K, ATPase activities were decreased (p<0.001) in rats under VPA treatment compared to the controls. These changes were more pronounced in valproate 60 days treated group than in valproate 30 days treated group. Oral administration of l-carnitine (L-CAR) at 300 mg/kg b. w. /day showed alleviation in all metabolic and physiologic changes in rats treated with sodium valproate. L-CAR supplementation might be recommended for human especially for epileptic persons subjected for long term to sodium valproate treatment.  

DOI

10.21608/ejhm.2007.17666

Keywords

Sodium valproate, L-carnitine, Epilepsy, Lipid profile, Malondialdehyde, catalase, Lactate dehydrogenase and Na, K- ATPase activities, muscle, Brain, bone and liver

Authors

First Name

Fahmy G.

Last Name

Elsaid

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Mansoura University, Egypt

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Orcid

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First Name

Fawzya E.

Last Name

Zeghiebr

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Affiliation

Zoology Department, Faculty of Science, Mansoura University, Egypt.

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Volume

28

Article Issue

1

Related Issue

3713

Issue Date

2007-07-01

Receive Date

2018-10-26

Publish Date

2007-07-01

Page Start

347

Page End

354

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 28_Issue 1_Pages 347-354.pdf

PDF . 272.6kB

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https://ejhm.journals.ekb.eg/article_17666.html

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https://ejhm.journals.ekb.eg/service?article_code=17666

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The effect of L-Carnitine on Sodium Valproate-Induced Physiological Disturbances in Rats

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Article

Created At

22 Jan 2023