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17664

The role of black seed and/ or bees honey in modulating the heart disorder induced by food additives in male rats.

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Last updated: 24 Dec 2024

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Abstract

Background: The present study aimed to throw the light on the potential hazards of some food additives whether preservatives such as sodium nitrite or colors as sunset yellow on the heart disorders through their own effect or the interaction between them. The study also, investigated the possible protective role of black seed and/ or bees honey against such risks. Results: Herein, the mentioned food additives caused significant elevations in serum and cardiac total lipids (TL), total cholesterol (TC), triglycerides (TG) and phospholipids (PL) levels as well as serum LDL-c, VLDL-c levels and LDL-c/HDL-c ratio. Meanwhile, significant decrements were shown in serum HDL-c level and HDL-c/TC ratio. Additionally, creatine kinase (CK) and aspartate transferase (AST) enzymes activity were increased significantly in serum and cardiac tissue. Moreover, oxidative stress markers; lipid peroxidation product (MDA) and protein carbonyl group (PC) were increased significantly in the cardiac tissue. Regarding, antioxidants; glutathione (GSH) content, glutathione -S -transferase (GST) and catalase (CAT) enzymes activity were decreased significantly in the cardiac tissue. Conclusion: However, the use of black seed and/ or bees honey ameliorated the disturbances observed indicating remarkable protection against the toxic effects of these food additives on the heart and offers more safety. Overall, here with the most pronounced effect was achieved by the combined treatment. In addition, the treatment by bees honey was more effective than black seed.  

DOI

10.21608/ejhm.2007.17664

Keywords

food additives, sunset yellow, Sodium Nitrite, Rats

Authors

First Name

Wafaa M.

Last Name

El-Kholy

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Mansoura University

Email

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City

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Orcid

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First Name

Hanaa A.

Last Name

Hassan

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Mansoura University

Email

drhanaahassan@mans.edu.eg

City

-

Orcid

-

First Name

Samar E.

Last Name

Nour

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Mansoura University

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-

City

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Orcid

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Volume

28

Article Issue

1

Related Issue

3713

Issue Date

2007-07-01

Receive Date

2018-10-26

Publish Date

2007-07-01

Page Start

327

Page End

341

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 28_Issue 1_Pages 327-341.pdf

PDF . 480.9kB

Link

https://ejhm.journals.ekb.eg/article_17664.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17664

Order

3

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The role of black seed and/ or bees honey in modulating the heart disorder induced by food additives in male rats.

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Article

Created At

22 Jan 2023