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Immunohistochemical Expression of P53 and Cyclin D1 Proteins in Follicular Thyroid Tumors: Evaluation of Their Significance

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Last updated: 03 Jan 2025

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Abstract

The sequential mutational events which may underlie the tumorigenesis of thyroid neoplasia are gradually becoming apparent. To clarify the role of P53 and cyclin D1 in the oncogenesis and tumor progression of thyroid neoplasms, we examined the immunoreactivity of these proteins in one hundred and thirty (130) thyroid tumors originating from the follicular epithelium using immunohistochemistry. The tumors were divided into two groups group I: included thirty five (35) follicular adenomas and group II: included ninety five (95) follicular carcinomas; 65 of which were well differentiated (WDC) while the remaining (30) were poorly differentiated (PDC). P53 positivity was more frequent in group II (20/95; 21.1%) than in group I (6/35; 17.1%) and in PDC (11/30; 26.6%) than WDC (9/65; 13.8%). On the other hand, cyclin D1 positivity was frequent in WDC (21/65; 32.3%) and rarely seen in adenoma group (2/35; 5.7%). Co –positivity for P53 and cyclin D1 proteins was more observed in PDC (5/30; 16.7%) than in WDC (3/65; 4.6%). The study suggested that cyclin DI may be involved in the thyroid oncogenesis and concluded that both proteins may be incriminated in the progression of follicular thyroid neoplasms. Moreover, we found that age at the time of diagnosis, the histologic differentiation, necrosis in primary tumor, extrathyroidal invasion and the presence of distant metastases are important prognostic and risk factors. In addition, our study revealed that the detection of P53, but not cyclin D1, in primary follicular carcinomas is a significant independent prognostic indicator which, together with the above mentioned important prognostic factors, may be of value in the theraputic planning of these tumors.  

DOI

10.21608/ejhm.2007.17701

Keywords

Thyroid gland – Follicular tumors – Immunohistochemistry- P53 – Cyclin D1- prognosis

Authors

First Name

Ahmed H. Abdel-Rahman

Last Name

El-Rashidy

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Affiliation

Departments of Pathology Al-Azhar(Assiut), Cairo & Al- Menya Universities

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Orcid

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First Name

Samir Abdel Salam A.

Last Name

Ibraheim

MiddleName

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Affiliation

General Surgery Al-Azhar(Assiut), Cairo & Al- Menya Universities

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Orcid

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First Name

Amer Yehia

Last Name

Mohamed

MiddleName

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Affiliation

General Surgery Al-Azhar(Assiut), Cairo & Al- Menya Universities

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Orcid

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First Name

Mohammed Hassan

Last Name

Fahmy

MiddleName

-

Affiliation

General Surgery Al-Azhar(Assiut), Cairo & Al- Menya Universities

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City

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Orcid

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First Name

Shehata

Last Name

AM

MiddleName

-

Affiliation

General Surgery Al-Azhar(Assiut), Cairo & Al- Menya Universities

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Volume

29

Article Issue

1

Related Issue

3712

Issue Date

2007-10-01

Receive Date

2018-10-27

Publish Date

2007-10-01

Page Start

566

Page End

577

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 29_Issue 1_Pages 566-577.pdf

PDF . 836.2kB

Link

https://ejhm.journals.ekb.eg/article_17701.html

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https://ejhm.journals.ekb.eg/service?article_code=17701

Order

9

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Immunohistochemical Expression of P53 and Cyclin D1 Proteins in Follicular Thyroid Tumors: Evaluation of Their Significance

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Article

Created At

22 Jan 2023