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17700

Role of Secretory Excretory Products of Schistosoma Mansoni Eggs in Modulating Hepatic Morbidity

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Last updated: 03 Jan 2025

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Abstract

In the present study the possible anti-morbidity effect of secretory excretory products (SEP) of Schistoma mansoni eggs (given to mice before infection) was investigated. Multiple small doses of SEP were injected intra-peritoneally into albino mice (100 μg of purified SEP followed 2 weeks later by two booster doses of 50 μg each at weekly intervals). Data revealed reduction in CD4+ cells and increase in CD8+ cells of hepatic granuloma in SEP-immunized infected group, resulting in significant decrease in CD4+/CD8+ ratio, in comparison to infected control group. The serum cytokine level of both TNF--alpha and IFN-gamma were also significantly decreased. Histopathological examination of liver revealed remarkable increase in degenerated ova within hepatic granuloma which decreased in diameter (12%). Significant reduction in worm burden (46%) and tissue egg loads (42.8% and 50% for hepatic and intestinal ova respectively) were observed. Mean while decreased percent of immature stages with increase in percent of dead ova in Oogram pattern was recorded. This work may help in decrease the severity of hepatic morbidity.

DOI

10.21608/ejhm.2007.17700

Authors

First Name

Ibrahim

Last Name

Rabia

MiddleName

-

Affiliation

Parasitology Department Theoder Bilharz Research Insitute, Giza ,Egypt

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Orcid

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First Name

Zeinab

Last Name

Fahmy

MiddleName

-

Affiliation

Parasitology Department Theoder Bilharz Research Insitute, Giza ,Egypt

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City

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Orcid

-

First Name

Hoda

Last Name

Sabry

MiddleName

-

Affiliation

Parasitology Departments Theoder Bilharz Research Insitute, Giza ,Egypt

Email

-

City

-

Orcid

-

First Name

Eman

Last Name

El-Ahwany

MiddleName

-

Affiliation

Immunology Departments Theoder Bilharz Research Insitute, Giza ,Egypt

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Orcid

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Volume

29

Article Issue

1

Related Issue

3712

Issue Date

2007-10-01

Receive Date

2018-10-27

Publish Date

2007-10-01

Page Start

557

Page End

565

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 29_Issue 1_Pages 557-565.pdf

PDF . 691.6kB

Link

https://ejhm.journals.ekb.eg/article_17700.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17700

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of Secretory Excretory Products of Schistosoma Mansoni Eggs in Modulating Hepatic Morbidity

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Article

Created At

22 Jan 2023