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17695

Genotoxicity of paracetamol on the germ cells of Drosophilla melanogaster

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Last updated: 03 Jan 2025

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Abstract

Paracetamol is a common analgesic and antipyretic drug. The aim of the present study is to determine the potential genetic effects of Paracetamol in Drosophilla melanogaster using two methods: Sex Linked Recessive Lethals (SLRL) test and effect of Paracetamol on enzyme activity using spectrophotometric analysis. Three concentrations of drug were used (5, 10, and 20 mM). The results reveal significant differences in S.L.R.L, except spermatozoa stages showed insignificant increases when the data of the four broods were considered all together in three treatments. Meanwhile, Paracetamol showed a genotoxic effects in the three categories of the two generations of S.L.R.L, F1 heterozygous females, F2 bar eye females and F2 wild type males on the genetic back ground of Cholinesterase in all treatments.

DOI

10.21608/ejhm.2007.17695

Authors

First Name

Saleha Y. M.

Last Name

alakilli

MiddleName

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Affiliation

Department of Biology, Faculty of science, King Abdelaziz University, Saudi Arabia

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Volume

29

Article Issue

1

Related Issue

3712

Issue Date

2007-10-01

Receive Date

2018-10-27

Publish Date

2007-10-01

Page Start

486

Page End

491

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 29_Issue 1_Pages 486-491.pdf

PDF . 284.3kB

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https://ejhm.journals.ekb.eg/article_17695.html

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https://ejhm.journals.ekb.eg/service?article_code=17695

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Genotoxicity of paracetamol on the germ cells of Drosophilla melanogaster

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Article

Created At

22 Jan 2023