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17694

Effect Of Dietary Supplementation With Tigernut Tubers On Streptozotocin-Induced Diabetic Rats

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Last updated: 03 Jan 2025

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Abstract

  This work has been carried out to detect the effect of tigernut tubers as an antidiabetic plant on some biochemical parameters in streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by a single intraperitoneal injection of 45 mg STZ /kg body weight. The present results indicated an increase in both serum glucose level and liver glucose-6- phosphatase (G6P) activity in STZ-diabetic rats. In addition, a significant decrease in serum insulin level and liver glycogen content was recorded in the same rats. Moreover, serum total lipids, total cholesterol, triglycerides and LDL-cholesterol levels revealed a significant increase, while a decrease in the level of HDL-cholesterol was observed in STZ-diabetic rats. The activity of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) showed marked increase in STZ-diabetic rats. On the other hand, tigernut- supplemented diet (25% w/w) for two or four weeks recorded a significant improvement in all the above biochemical parameters affected by STZ injection especially after four weeks of treatment. Therefore, it was concluded that tigernut tubers had appreciable hypoglycemic and hypolipidemic effects on STZ-diabetic rats.  

DOI

10.21608/ejhm.2007.17694

Keywords

Tigernut (Cyperus esculentus) – STZ-diabetic rats – lipid profiles

Authors

First Name

H. A.

Last Name

Hassan

MiddleName

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Affiliation

Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt.

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Volume

29

Article Issue

1

Related Issue

3712

Issue Date

2007-10-01

Receive Date

2018-10-27

Publish Date

2007-10-01

Page Start

475

Page End

485

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 29_Issue 1_Pages 475-485.pdf

PDF . 346.4kB

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https://ejhm.journals.ekb.eg/article_17694.html

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https://ejhm.journals.ekb.eg/service?article_code=17694

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect Of Dietary Supplementation With Tigernut Tubers On Streptozotocin-Induced Diabetic Rats

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Article

Created At

22 Jan 2023