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Pentoxifylline As A Radioprotector Against Certain Biochemical And Metal Disorders Of Whole Body Gamma Irradiation In Rats

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Last updated: 03 Jan 2025

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Abstract

Introduction :- The effect of whole body gamma irradiation at 6.5 Gy dose level on some biochemical indices and metal levels has been investigated in albino rats. Material And Method:- These included the determination of lipid peroxidation and metallothionein (MT) in liver and kidney. Iron, copper and zinc were measured in liver, kidney spleen and intestine. Also the P50 of survival was determined in rats. Results:- For the control of these radiation-induced disorders, the radioprotective character of pentoxifylline has been evaluated. Acute γ-radiation-induced disturbances in trace metals levels in some organs were studied; specially Fe concentrations which were significantly increased (p≤0.05) in liver, spleen and intestine. Also γ-radiation-induced increase in malonaldehyde (MDA) levels as lipid peroxidation indicator and decrease metallothionein (MT)-induction as antioxidant defense induced in the cell. Pre-treatment with pentoxifylline was not effective against the changes produced by acute γ-radiation on metals studied, lipid peroxidation process and MT-induction. While post treatment showed positive effect on liver iron and metallothionein levels in liver and kidney.  

DOI

10.21608/ejhm.2008.17659

Keywords

Pentoxifylline, Radioprotector, Gamma Irradiation, Metals

Authors

First Name

Esmat A.

Last Name

Shaban

MiddleName

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Affiliation

Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo (Egypt)

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First Name

Asrar M.

Last Name

Hawas

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Affiliation

Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo (Egypt)

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Volume

30

Article Issue

1

Related Issue

3703

Issue Date

2008-01-01

Receive Date

2018-10-26

Publish Date

2008-01-01

Page Start

133

Page End

144

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 30_Issue 1_Pages 133-144.pdf

PDF . 388.3kB

Link

https://ejhm.journals.ekb.eg/article_17659.html

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https://ejhm.journals.ekb.eg/service?article_code=17659

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Pentoxifylline As A Radioprotector Against Certain Biochemical And Metal Disorders Of Whole Body Gamma Irradiation In Rats

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Article

Created At

22 Jan 2023