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17653

Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomiasis among Egyptian patients

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Last updated: 03 Jan 2025

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Abstract

Introduction: Schistosomiasis is considered as a widespread problem that affects Egyptians at different ages (WHO, 1993). It is well known that the high incidence of bladder carcinoma in schistosomal patients also represents a great risk to Egyptian society. Objective: This study represents a survey on the changes which took place in Alpha- Fetoprotein (AFP) levels as a differential marker among Egyptian patients suffering from urinary bilharzial infection and bladder cancer. Methodology: A partial study was carried out on four post-operative patients and followed up for sixty three days after chemotherapeutic treatment using immunoenzymatic mediated assay. Results: It was found that bladder cancer leads to obvious significant increase in AFP levels, while schistosomal infection causes a non-significant decrease as compared to healthy control. Although the combination between schistosomal infection and cancer leads to a significant decrease in AFP level compared to non bilharzial cancer cases, there was no significant correlation with healthy cases. Conclusion: It should be pointed out that the somewhat constant level of AFP in the sera of all patients was due to chemotherapeutic treatment. Also, it can be noticed that there is a significant positive correlation with progress of cancer grades.  

DOI

10.21608/ejhm.2008.17653

Keywords

alpha-fetoprotein, schistosomal infection, urinary bilharzial infection and bladder cancer

Authors

First Name

Maghraby

Last Name

A.S

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Affiliation

Therapeutic Chemistry Department National Research Center, Dokki, Cairo. Infectious Diseases and Immunology group, Center of Excellence for Advanced Studies

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First Name

Samia A.

Last Name

Ahmed

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-

Affiliation

Therapeutic Chemistry Department National Research Center, Dokki, Cairo.

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Orcid

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First Name

Ayman M.

Last Name

Metwally

MiddleName

-

Affiliation

Technology of Medical Laboratory Department, College of Applied Medical Sciences, Misr University For Science and Technology, 6th of October, Egyp

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Orcid

-

First Name

Khalid

Last Name

H

MiddleName

-

Affiliation

National Cancer Institute, Cairo

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Volume

30

Article Issue

1

Related Issue

3703

Issue Date

2008-01-01

Receive Date

2018-10-26

Publish Date

2008-01-01

Page Start

62

Page End

69

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 30_Issue 1_Pages 62-69.pdf

PDF . 1.5MB

Link

https://ejhm.journals.ekb.eg/article_17653.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17653

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6

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Alpha-fetoprotein as a differential marker between bladder cancer and Schistosomiasis among Egyptian patients

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Article

Created At

22 Jan 2023