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17647

Interferon gamma Profile in Egyptian Infants with Respiratory Syncytial Virus bronchiolitis

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Last updated: 03 Jan 2025

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Abstract

Viral bronchiolitis is one of the leading causes for hospitalization of infants in the world and causes an estimated one million deaths per year worldwide. Respiratory syncytial virus (RSV) is associated with the majority of cases. During the last few years it has become increasingly clear that T cells contribute to the abnormal regulation of the immune response in viral diseases since these cells are potent producers of a large variety of cytokines. It was reported that cord blood interferon gamma (IFN-γ) responses were inversely related to the frequency of viral respiratory infections. To ascertain whether RSV infection promotes a different IFN-γ profile to that induced by other respiratory infections, thirty-two infants with severe bronchiolitis were enrolled in this study. RSV-IgM was detected by immunofluorescent technique in 23/32 patients. Serum IFN-γ levels in RSV+ infants were significantly lower than RSV- (p < 0.001). In vitro stimulation of peripheral blood cells followed by flow cytometery combined with intracellular cytokine staining revealed that both CD4+ and CD8+ cells contribute in IFN-γ production. The percentage of CD4+ cells producing IFN-γ in RSV+ was significantly lower (P < 0.05) than those in RSV-, while the difference in % of CD8+ between RSV+ and RSV- was non significant. Our conclusions are that RSV infection is associated with severe decreased IFN-γ responses. Both CD4+ and CD8+ cells contribute in IFN-γ production during RSV bronchiolitis. RSV infection promotes a different IFN-γ profile from that induced by other respiratory infections.

DOI

10.21608/ejhm.2008.17647

Authors

First Name

Maha E.

Last Name

Omran

MiddleName

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Affiliation

Microbiology and Immunology Department Faculty of Pharmacy (for Girls),

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Orcid

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First Name

Mohamed AE

Last Name

. Fahmy

MiddleName

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Affiliation

Medical Biochemistry Department Faculty of Medicine

Email

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Orcid

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First Name

Manal M.

Last Name

Zaher

MiddleName

-

Affiliation

Pediatric Department Faculty of Medicine (for Girls) - Al-Azhar University

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Orcid

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Volume

30

Article Issue

1

Related Issue

3703

Issue Date

2008-01-01

Receive Date

2018-10-26

Publish Date

2008-01-01

Page Start

1

Page End

13

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 30_Issue 1_Pages 1-13.pdf

PDF . 392.9kB

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https://ejhm.journals.ekb.eg/article_17647.html

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https://ejhm.journals.ekb.eg/service?article_code=17647

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Interferon gamma Profile in Egyptian Infants with Respiratory Syncytial Virus bronchiolitis

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Article

Created At

22 Jan 2023