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17624

The Toxicological effects of fenitrothion and vitamin E as antioxidant agent on the biochemical, cytogenetic and histopathological parameters of white rats

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Last updated: 24 Dec 2024

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Abstract

Background: The use of pesticides has been increased considerably nowadays compared to the past. The hazards of using such chemical compounds have been accentuated by the sharp rise of their use in agriculture, industry, by householders and governments. Exposure to organophosphorus insecticides (OPI) in agriculture is one of the occupational hazards. Fenitrothion is one of the most important OPI. The major object of the present study was to evaluated the toxicological (biochemical, mutagenic and histopathological) effects of tested insecticide "fenitrothion" alone or combined to vitamin E as an antioxidant agent to decrease their toxic effect.
Material and Method male albino rats were tested orally for 30 days, three doses of fenitrothion were used in absence and presence of vitamin E (1/20, 1/40 and 1/80 LD50).
Results the obtained data showed marked changes in biochemical parameter, highly inhibition of AchE activity; highly significant increase in the frequency of micronucleus (PCEM) in rat bone marrow cells at all doses of fenitrothion alone or combined to vitamin compared to control group. Also, the histopathological examination of liver and kidney tissues revealed high alternation in these tissues corresponding to biochemical changes.
Conclusion From these results we concluded that fenitrothion exert biochemical, mutagenic and histopathological effects in white rats. In addition, vitamin E has mild role in alleviating these toxicological effects.
 

DOI

10.21608/ejhm.2008.17624

Keywords

Organophosphorus, fenitrothion, antioxidant agent, micronucleus

Authors

First Name

Fouad

Last Name

Abdel Reheim

MiddleName

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Affiliation

Department of Biochemistry, Faculty of Agriculture, Cairo University

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Orcid

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First Name

Awad Abbas

Last Name

Ragab

MiddleName

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Affiliation

Department of Biochemistry, Faculty of Agriculture, Cairo University

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Orcid

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First Name

Fatma.M.

Last Name

Hammam

MiddleName

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Affiliation

Department of Mammalian Toxicology, Central Agricultural Pesticides Laboratory, Agricultural Research Centre.

Email

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City

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Orcid

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First Name

Hossam El-Din

Last Name

Hamdy

MiddleName

-

Affiliation

Department of Mammalian Toxicology, Central Agricultural Pesticides Laboratory, Agricultural Research Centre.

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Volume

33

Article Issue

1

Related Issue

3700

Issue Date

2008-10-01

Receive Date

2018-10-25

Publish Date

2008-10-01

Page Start

604

Page End

421

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 33_Issue 1_Pages 604-421.pdf

PDF . 1.1MB

Link

https://ejhm.journals.ekb.eg/article_17624.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17624

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Toxicological effects of fenitrothion and vitamin E as antioxidant agent on the biochemical, cytogenetic and histopathological parameters of white rats

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Article

Created At

22 Jan 2023