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17577

Antioxidant, hepatoprotective and immuno-stimulant effects of nutraceutical compounds from carotenoid origin in rat treated with carbon tetrachloride

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Last updated: 24 Dec 2024

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Abstract

Aim of the work: the present study was conducted to evaluate antioxidant, hepatoprotective, and immuno-stimulant properties of carotenes derived from food byproducts (tomato peels (TPW), mango peels (MP), corn gluten (CG), and agriculture dill waste (DW)), they were selected for their high superoxide dismutase activity (SOD). Material and methods: antioxidant and hepatoprotective effects were investigated in carbon tetrachloride (CCl4) damaged liver. Rats treated with oral doses of each carotene (25 mg /Kg b.wt.) for 15 days prior CCl4 administration and 4 days post- CCl4-treatment.
Results: all tested carotenes significantly reduced the elevated values of liver function tests (GGT, ALT & AST) in hepatic damaged groups as well as, they had an immuno-stimulate property. They increased IgG levels in normal and liver damaged rats treated with the tested carotenoids. Whereas, IgG level reduced significantly by CCl4-tereatment. Histopathological examination of the liver tissues exposed to CCl4 showed inflammatory cell infiltration, necrosis and fibrosis. Glycogen and total protein contents also recorded. Treatments with carotenoids led to an improvement in the histological and histochemical alterations induced by CCl4. Conclusion, carotenes may play an important role as nutraceutical preparation, specially, when obtained from wastes of food byproducts in which economically of low coast production.

DOI

10.21608/ejhm.2009.17577

Keywords

antioxidant, Hepatoprotective, histopathology, Nutraceutical, Carotenoids

Authors

First Name

Enayat A. M.

Last Name

Omara

MiddleName

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Affiliation

Pathology Dept National Research Centre, Dokki, Cairo, Egypt

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Orcid

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First Name

Somaia A.

Last Name

Nada

MiddleName

-

Affiliation

Pharmacology Dept National Research Centre, Dokki, Cairo, Egypt

Email

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City

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Orcid

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First Name

Hanan G.

Last Name

Zahran

MiddleName

-

Affiliation

Clinical Chemistry Dept., National Research Centre, Dokki, Cairo, Egypt

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Orcid

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Volume

35

Article Issue

1

Related Issue

3687

Issue Date

2009-04-01

Receive Date

2018-10-25

Publish Date

2009-04-01

Page Start

295

Page End

308

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 35_Issue 1_Pages 295-308.pdf

PDF . 1.7MB

Link

https://ejhm.journals.ekb.eg/article_17577.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17577

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Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Antioxidant, hepatoprotective and immuno-stimulant effects of nutraceutical compounds from carotenoid origin in rat treated with carbon tetrachloride

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Article

Created At

22 Jan 2023