Aim of the work: The current study was conducted to evaluate the protective effect of the ethanolic extract of jojoba in rats treated with fumonisin. Material and Method: Forty mature male Sprague–Dawley rats were divided into four groups included the control groups and the groups treated with fumonisin-contaminated cultural materials (60 mg/L), the group treated orally with jojoba extract (5 mg/kg b.w) and the group treated with fumonisin and the extract. Results: the results indicated that fumonisin induced a significant decrease in RBCs, HB, platelets, WBCs and triglycerides accompanied with a significant increase in all the other biochemical parameters tested. Moreover, animals treated with fumonisin alone showed severe pathological and histochemical changes in the liver tissues. Animals treated with jojoba extract alone were comparable to the controls regarding the haematological, the biochemical parameters, the histological structure and histochemical picture of the liver.  In conclusion: The extract contracted the toxic effects of fumonisin and succeeded to normalize all the parameters tested and improve the histological and histochemical structure of the liver.