Skin and psyche share embryonic origins, various psychological factors, including emotional trauma and stressful life events, may affect both onset and progression of some skin conditions, Psoriasis is a chronic skin disease with substantial impact on patient's social and relational ways of living and subsequently on their quality of life. This chronic condition has a significant negative impact on patients' quality of life. Psoriasis has been linked to patients depression and suicidal tendencies Patients and Methods The study group consisted of 50 consenting consecutive cases of psoriasis vulgaris, of both sexes, aged 18-62 years (41.44 ± 0.101), and with duration of the disease 6-10 years, attending the dermatology outpatient clinic of Al Zahraa university hospital. The extent of clinical severity of the disease was assessed by the psoriatic area and severity index (PASI Score), Assessment of quality of life of patients by Lehman Quality of Life Interview (LQLI) .According toPASI score they were devided into 3groups :mild cases were treated by topical steroid and salyslic acid while moderate cases were treated by NB-UVB and severe cases were treated by systemic methotrexate. Results showed that 57.4% of patients were unsatisfied with their family relations and 43.5% are satisfied. However, about their social relations they were 55.3% satisfied while 44.6% were unsatisfied. In the other hand, they were 52.3% satisfied with their finance while the other 48.2% were unsatisfied with it. As regard, work or school they were 66.4% satisfied and 33.5% unsatisfied. While they were 85.1% satisfied with low, safety, and 14.8% unsatisfied. The same for health 94.4% satisfied and 6.5% unsatisfied .The third group treated by systemic methotrexate show marked increase in LQLI. Conclusions: Psoriasis is a disease with profound impact on the psychological and social aspect of the patient, particularly because of its visibility. Systemic therapy of psoriasis could improve their quality of life. Thus assessment by a health professional of the extent of apparent disease in terms of the clinical severity alone may not suffice, and a more holistic approach to the quality of life is mandatory.