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17488

Effects of the methanolic extracts of Zizyphus spina christi, Olea europaea and Morus alba leaves in Streptozotocin- induced diabetic rats.

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Last updated: 03 Jan 2025

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Abstract

Background:The present study aims to investigate the hypoglycemic, hypolipidimic and antioxidant effect of the methanolic crude extracts of Zizyphus spina christi, Morus alba and Olea europaea leaves, individually or in combination against diabetes induced rats by Streptozotocin (STZ). Results:Hyperglycemia and hyperlipidaemia except in high density lipoproteins (HDL) were observed in serum after 5 weeks of STZ administration. This was associated with a depression in hepatic glutathione (GSH) concentration as well as hepatic catalase (CAT), glutathione-s- transferase (GST) and superoxide dismutase (SOD) activates. In addition hepatic thiobarbituric acid-reactive substance (TBARS) and protein carbonyl (PC) were significantly elevated, indicating increased lipid and protein oxidation and oxidative stress. Depression in blood hemoglobin (Hb) content, serum insulin levels, total antioxidant capacity (TAOC) and nitric oxide (NO) levels as well as body weight gain were also observed in diabetic rats. Administration of 100mg/kg alcoholic extracts of Zizyphus spina christi, Morus alba and Olea europaea leaves 3 days before and after STZ injection daily for 5 weeks significantly ameliorated the oxidative stress evidenced by lowering TBARS & PC as well as increasing hepatic GSH concentration and CAT, GST and SOD activates as compared with STZ treated rats. These effects were paralleled with marked protection against STZ induced hyperglycemia and disturbance of lipid profile. They also caused a great improvement in insulin levels, TAOC, NO, Hb content and body weight gain. Conclussion:Thus, these results showed that the administration of the crude extracts of either Zizyphus spina christi, Morus alba or Olea europaea leaves individually or in combination might improve the clinical manifestation of diabetes and decrease the oxidative stress, this study supports the beneficial effects of these extracts especially Zizyphus spina christi, which showed marked amelioration and this may be attributed to the presence of saponin glycosides which have an inhibitory effect of serum glucose level in addition to enhance the cellular antioxidant defense. This activity contributes to the protection against oxidative damage in STZ induced diabetes.  

DOI

10.21608/ejhm.2009.17488

Keywords

diabetes, Zizyphus spina-christi, Olea europaea, Morus alba, antioxidants, lipids, Oxidative stress markers, Nitric oxide

Authors

First Name

A. I.

Last Name

Othman

MiddleName

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Affiliation

Zoology Department Faculty of Science, Mansoura University, Mansoura, Egypt

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Orcid

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First Name

M. A.

Last Name

Amer

MiddleName

-

Affiliation

Zoology Department Faculty of Science, Mansoura University, Mansoura, Egypt

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Orcid

-

First Name

R. F.

Last Name

Samaha

MiddleName

-

Affiliation

Zoology Department Faculty of Science, Mansoura University, Mansoura, Egypt

Email

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City

-

Orcid

-

First Name

M.

Last Name

Abdel-Mogib

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt

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Volume

37

Article Issue

1

Related Issue

3685

Issue Date

2009-10-01

Receive Date

2018-10-24

Publish Date

2009-10-01

Page Start

759

Page End

771

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 37_Issue 1_Pages 759-771.pdf

PDF . 374.5kB

Link

https://ejhm.journals.ekb.eg/article_17488.html

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https://ejhm.journals.ekb.eg/service?article_code=17488

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13

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effects of the methanolic extracts of Zizyphus spina christi, Olea europaea and Morus alba leaves in Streptozotocin- induced diabetic rats.

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Article

Created At

22 Jan 2023