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17482

Studies on the effect of antioxidant Selenium-ACE after treatment with Praziquantel and Mirazid in Schistosoma mansoni infected mice

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Last updated: 24 Dec 2024

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Abstract

Background: This study deals with the evaluation of parasitological, histopathological and biochemical effect of Praziquantel (PZQ) and Mirazid (MZ) with or without Selenium-ACE (Se-ACE) on male albino mice infected with S.mansoni and trying to evaluate the antioxidant effect of Se-ACE and its role in reducing the severity of the infection. Results: The obtained results indicated that treatment with PZQ produced more reduction in worm burden and ova count/gm liver than MZ compared to the infected control group. PZQ showed the highest reduction in liver granuloma number and diameter when compared to MZ group while both drugs showed a significant effect in restoration of the liver transaminases and protein fractions towards their normal levels indicating the safety of both drugs as anti S. mansoni chemotherapeutics, Se-ACE showed a high efficacy as a co-treatment, potentiating the effect of PZQ and MZ in reducing the worm burden, ova count/gm liver, number and diameter of liver granuloma and restoration of liver transaminases and protein fractions to their normal levels during treatment of S. mansoni infection. Conclusion: the rank order of potency in protection against liver cell damage was PZQ 500 mg/kg > MZ 600 mg/kg where Se-ACE showed a couraging criterion as a co- treatment potentiating the effect of the antischistosomal medications through its anti- oxidant activity.  

DOI

10.21608/ejhm.2009.17482

Keywords

praziquantel, Mirazid, Selenium –ACE, S. mansoni and co-treatment

Authors

First Name

Muhammad Hamdy

Last Name

Emam

MiddleName

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Affiliation

Parasitology Department, Faculty of Medicine, Al-Azhar University

Email

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City

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Orcid

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First Name

Mona

Last Name

Abd El-Rahman

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Helwan University

Email

-

City

-

Orcid

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First Name

Irene Sameh

Last Name

Gamil

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Helwan University

Email

-

City

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Orcid

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First Name

Marwa Ahmed

Last Name

Muselhy

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Helwan University

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-

City

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Orcid

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Volume

37

Article Issue

1

Related Issue

3685

Issue Date

2009-10-01

Receive Date

2018-10-24

Publish Date

2009-10-01

Page Start

709

Page End

725

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 37_Issue 1_Pages 709-725.pdf

PDF . 684.4kB

Link

https://ejhm.journals.ekb.eg/article_17482.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17482

Order

9

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Studies on the effect of antioxidant Selenium-ACE after treatment with Praziquantel and Mirazid in Schistosoma mansoni infected mice

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Article

Created At

22 Jan 2023