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17481

Allelic Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Coronary Artery Diseases

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Last updated: 24 Dec 2024

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Abstract

Nitric oxide (NO) has an important role in the relaxation of the vascular smooth muscles, inhibits adhesion of platelets and leucocytes to the endothelium, reduces vascular smooth muscle cells migration and proliferation and limits the oxidation of atherogenic LDL.
Nitric oxide is constitutively produced in the endothelium of blood vessels from L- arginine by the enzyme endothelial nitric oxide synthase (eNOS).
Polymorphism in the (eNOS) gene is an important risk factor in the pathophysiology of coronary artery disease( CAD) .
In this study the polymorphism in (eNOS) gene was investigated in 30 patients with CAD and 20 control subjects using polymerase chain reaction (PCR) analysis. Patients were classified into 10 patients with unstable angina and 20 patients with myocardial infarction Results : The distribution of (eNOS) genotypes in patients affected by unstable angina was 50% for GG genotype , 40% for GT genotype and 10% for TT genotype and in patients affected by myocardial infarction was (45%) for GG genotype, (35%) for GT genotype and (20%) for TT genotype. In control subjects it was (50%) for GG genotype, (45%) for GT genotype and (5%) for TT genotype.
Conclusion: there is a great controversy about the role of (eNOS) gene polymorphism in the pathophysiology of CAD.

DOI

10.21608/ejhm.2009.17481

Authors

First Name

Omnia H.

Last Name

Seoudi

MiddleName

-

Affiliation

Med. Biochemistry Department, Faculty of Medicine for Girls, Al-Azhar University

Email

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City

-

Orcid

-

First Name

Effat M.

Last Name

Abo El-kheir

MiddleName

-

Affiliation

Med. Biochemistry Department, Faculty of Medicine for Girls, Al-Azhar University

Email

-

City

-

Orcid

-

First Name

Nareman M.

Last Name

Younees

MiddleName

-

Affiliation

Med. Biochemistry Department, Faculty of Medicine for Girls, Al-Azhar University

Email

-

City

-

Orcid

-

First Name

Olfat G

Last Name

Shaker

MiddleName

-

Affiliation

Med. Biochemistry Department, Faculty of Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Hala M.

Last Name

El-mogy

MiddleName

-

Affiliation

Med. Biochemistry Department, Faculty of Medicine for Girls, Al-Azhar University

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Volume

37

Article Issue

1

Related Issue

3685

Issue Date

2009-10-01

Receive Date

2018-10-24

Publish Date

2009-10-01

Page Start

700

Page End

708

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 37_Issue 1_Pages 700-708.pdf

PDF . 506.7kB

Link

https://ejhm.journals.ekb.eg/article_17481.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17481

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Allelic Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Coronary Artery Diseases

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Article

Created At

22 Jan 2023