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Low Dose Gamma Irradiation Modifies the Effect of L-Carnitine, Curcumin, Garlic Powder and Green tea Extract on Doxorubicin-Induced Nephropathy in Rats

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Last updated: 03 Jan 2025

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Abstract

The possible protective potential of exposure to low dose of γ radiation in presence or absence of L-carnitine, curcumin, garlic powder or green tea extract was examined in the present study on doxorubicin (DOX)-induced experimental nephropathy in rats. Preliminary study was carried out to select the suitable dose of DOX to induce nephrotoxicity. In the current experiment 5 mg/kg, i.p. was selected as a single dose to induce nephrotoxicity during 15 days. The possible modulating effect of L-carnitine, curcumin, garlic powder or green tea extract on kidney function was examined. Animals were subdivided into three sets. Three groups of the 1st set were exposed to γ radiation at a single dose level of 0.3 Gy then received DOX, 1, 3 or 7 days postirradiation respectively. The groups of 2nd set daily received L-carnitine (40 mg/kg, i.p.), curcumin (50 mg/kg, i.p.), garlic powder (100 mg/kg, p.o.) and green tea extract (300 mg/kg, p.o.) daily for two weeks before induction of nephropathy. Groups of the 3rd set received the same doses of drugs then were injected with DOX, 1, 3 or 7 days following γ irradiation respectively. Two groups of animals, one of them received saline and served as normal and the other received DOX and served as nephropathic group were included in 1st, 2nd as well as 3rd set. Fifteen days following DOX administration, serum was collected and the animals were then sacrificed. Serum creatinine, urea and uric acid were evaluated. Data revealed that, a single DOX dose (5 mg/kg) induced marked acute nephrotoxicity manifested as significant increase in the activities of serum creatinine, urea as well as uric acid. Interestingly, pre-exposure to γ radiation at a dose level of 0.3 Gy, 1 or 3 days before DOX injection exhibited significant improvement in the above altered mentioned parameters. However, exposure to low dose radiation 7 days prior to DOX administration did not show a protective effect. Moreover, pretreatment with L-carnitine, curcumin, garlic powder or green tea extract in rats unexposed or exposed to γ radiation before DOX administration ameliorated, to a great extent, the effects induced by DOX. The present findings suggest that exposure to a single low dose of γ radiation (0.3 Gy) one day before DOX administration is a promising approach for maximizing the nephroprotective effects of L-carnitine, curcumin, garlic powder or green tea extract with minimal adverse effects of DOX.  

DOI

10.21608/ejhm.2010.17384

Keywords

Doxorubicin, 0.3 Gy γ radiation, L-carnitine, Curcumin, garlic powder, Green tea extract, creatinine, urea and uric acid

Authors

First Name

Rasha R.

Last Name

Radwan

MiddleName

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Affiliation

Department of drug radiation research, National Center for Radiation Research and Technology, Atomic Energy Authority.

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Orcid

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First Name

Esmat A.

Last Name

Shaban

MiddleName

-

Affiliation

Department of drug radiation research, National Center for Radiation Research and Technology, Atomic Energy Authority.

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City

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Orcid

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First Name

Hesham A.

Last Name

Salem

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, CairoUni.

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Orcid

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First Name

Sanaa A.

Last Name

Kenawy

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, CairoUni.

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Volume

40

Article Issue

1

Related Issue

3652

Issue Date

2010-07-01

Receive Date

2018-10-23

Publish Date

2010-07-01

Page Start

350

Page End

364

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 40_Issue 1_Pages 350-364.pdf

PDF . 496.5kB

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https://ejhm.journals.ekb.eg/article_17384.html

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https://ejhm.journals.ekb.eg/service?article_code=17384

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Low Dose Gamma Irradiation Modifies the Effect of L-Carnitine, Curcumin, Garlic Powder and Green tea Extract on Doxorubicin-Induced Nephropathy in Rats

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Article

Created At

22 Jan 2023