Background: Acute cholecystitis- inflammation of the gall bladder- is most usually brought on by gall stones. Gall stones are one of the most typical problems of the gastrointestinal system, impacting regarding 10% of individuals in Western world. Aim of the study: In this review we discussed background of cholecystitis, symptoms and possible complications. As well we highlighted importance and use of ultrasound in diagnosis of cholecystitis and other diagnoses possibilities and their efficiency. Materials:   Articles search was performed in MEDLINE, EMBASE, and CINAHL databases up to May 2018 to identify studies about evaluation ultrasound in diagnosis of cholecystitis and other diagnoses possibilities and their efficiency. Conclusion:    CT is debatably the most effective technique for imaging of challenging gallbladder condition, especially for straight imaging of emphysematous cholecystitis, gallstone ileus, and verification of presumed gallbladder perforation. Cholescintigraphy may assist ultrasound and CT for differentiating acute from chronic cholecystitis and for the diagnosis of acalculous cholecystitis.