Beta
17504

Evaluation of Diagnosis and Management Plan of Diabetes Mellitus Related Cystic Fibrosis in Children

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

-

Abstract

Background: Cystic fibrosis (CF) is a disease that occurs as a result of genetic mutations in cystic fibrosis transmembrane conductance regulator gene (CFTR). CFTR can be found in airways epithelial cells, intestine and cells with exocrine and exocrine function. CF is associated with variant complications, Cystic Fibrosis-Related Diabetes (CFRD) is considered as one of the most common complications of CF. Objective: In this review, we discussed the recent updates about Cystic Fibrosis-Related Diabetes (CFRD) diagnosis and management plan. Methods: PubMed database were used for articles selection. All relevant articles related to our review were chosen to cover the following topics: Cystic Fibrosis, Cystic Fibrosis Related Diabetes management, Cystic Fibrosis Related Diabetes diagnosis. We excluded other articles, which are not related to our objectives. Conclusion: CFRD can significantly worse the health condition of CF patients. However, with the recent advancement of management plans of CFRD, previous sex differences in mortality have disappeared and that the gap in mortality between CF patients with diabetes and CF patients without diabetes has considerably narrowed. Early diagnosis and early intervention also helped in improving the quality of CFRD patients and preventing the complications. This can be obtained by annual screening for DM among CF patients since 10 years of age using OGTT as recommended by ADA. The primary pathologic feature of CFRD is insulin insufficiency. It leads to increased breakdown of protein and fat. So, insulin replacement is the only recommended medical treatment and it has been shown to improve clinical outcomes. Oral diabetes agents are usually not recommended in CFRD.

DOI

10.21608/ejhm.2018.17504

Keywords

Evaluation, management plan, Diabetes mellitus, Cystic fibrosis, children

Authors

First Name

Eyman Abdulmajeed

Last Name

Alfaraj

MiddleName

-

Affiliation

Imam Abdulrahman bin Faisal University

Email

-

City

-

Orcid

-

First Name

Fatimah Mohammed

Last Name

AlOmran

MiddleName

-

Affiliation

Imam Abdulrahman bin Faisal University

Email

-

City

-

Orcid

-

First Name

Hassan Abdullah

Last Name

Alashwan

MiddleName

-

Affiliation

Imam Abdulrahman bin Faisal University

Email

-

City

-

Orcid

-

First Name

Abdullah Jameel

Last Name

Almajed

MiddleName

-

Affiliation

Imam Abdulrahman bin Faisal University

Email

-

City

-

Orcid

-

First Name

Redha Ali

Last Name

Alsaleh

MiddleName

-

Affiliation

Imam Abdulrahman bin Faisal University

Email

-

City

-

Orcid

-

First Name

Hassan Abdulmohsen

Last Name

Alhumrran

MiddleName

-

Affiliation

Imam Abdulrahman bin Faisal University

Email

-

City

-

Orcid

-

First Name

Rawan Abdulqawi

Last Name

Bobakr

MiddleName

-

Affiliation

Umm Al-Qura University

Email

-

City

-

Orcid

-

First Name

Seham Matar

Last Name

Alotaibi

MiddleName

-

Affiliation

Umm Al-Qura University

Email

-

City

-

Orcid

-

First Name

Nouf ghazi S.

Last Name

Abuhekmah

MiddleName

-

Affiliation

King Khaled university

Email

-

City

-

Orcid

-

First Name

Nasser Subeeh

Last Name

Alshammri

MiddleName

-

Affiliation

Jordan University of Sciences and Technology

Email

-

City

-

Orcid

-

Volume

73

Article Issue

7

Related Issue

3621

Issue Date

2018-10-01

Receive Date

2018-10-24

Publish Date

2018-10-01

Page Start

7,069

Page End

7,076

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_17504.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17504

Order

13

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Evaluation of Diagnosis and Management Plan of Diabetes Mellitus Related Cystic Fibrosis in Children

Details

Type

Article

Created At

22 Jan 2023