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16970

Adiponectin multimers in patients with Barrett’s Oesophagus

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Last updated: 03 Jan 2025

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Abstract

Barrett's oesophagus is associated with abdominal obesity. Adiponectin is a peptide that is secreted from adipocytes and circulates in three multimeric forms: low molecular weight (LMW), middle molecular weight (MMW), and high molecular weight (HMW). The anti- inflammatory effects of adiponectin are specific to individual multimers, with the LMW being most anti-inflammatory. We investigated the possibility that circulating levels of adiponectin and its multimers would be associated with the risk of Barrett's oesophagus. Subjects and methods This study comprised patients diagnosed to have Barrett's oesophagus, and control subjects diagnosed to have gastrooesophageal reflux disease (GORD), all were diagnosed in the gastroenterology and endoscopy unit, King Fahd hospital, Riyadh, Saudi Arabia.
Plasma adiponectin levels and its multimers were evaluated for patients with Barrett's oesophagus and controls with GORD. Results There were 120 cases of Barrett's oesophagus and 250 GORD controls. Total adiponectin was not significantly associated with Barrett's oesophagus; low levels of LMW adiponectin and low LMW/total ratio were significantly present in patients with Barrett's oesophagus. Conclusion Low levels of LMW adiponectin are significantly associated with Barrett's oesophagus.

DOI

10.21608/ejhm.2018.16970

Keywords

Barrett’s oesophagus, GORD, abdominal obesity, adiponectin

Authors

First Name

Mohammed

Last Name

Fakhraldeen

MiddleName

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Affiliation

Faculty of medicine, Mansoura University

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City

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Orcid

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First Name

Huseen Saad

Last Name

Mostafa

MiddleName

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Affiliation

King Fahd hospital, Riadh ,Saudi Arabia

Email

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City

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Orcid

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First Name

Ghada Ali

Last Name

Abdulwahab

MiddleName

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Affiliation

King Fahd hospital, Riadh, Saudi Arabia

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Orcid

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Volume

39

Article Issue

1

Related Issue

3582

Issue Date

2018-04-01

Receive Date

2018-10-19

Publish Date

2018-04-01

Page Start

268

Page End

274

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 39_Issue 1_Pages 268-274.pdf

PDF . 238.5kB

Link

https://ejhm.journals.ekb.eg/article_16970.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16970

Order

13

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Adiponectin multimers in patients with Barrett’s Oesophagus

Details

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Article

Created At

22 Jan 2023