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Anticarbohydrate antibodies in patients with inflammatory bowel disease.

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Last updated: 03 Jan 2025

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Abstract

Evaluating
antilaminaribioside carbohydrate antibodies (ALCA), antimannobioside carbohydrate antibodies (AMCA) and anti-Saccharomyces cerevisiae antibodies (ASCA), in patients with inflammatory bowel disease (IBD). Subjects and methods: 268 serum samples were used; 115 Crohn's disease (CD), 83 ulcerative colitis, and 70 healthy control samples. All samples were evaluated using enzyme-linked immunosorbent assay for the following four anticarbohydrate antibodies: ACCA, ALCA, AMCA, and ASCA. Results: In patients with Crohn's disease the prevalence of the anticarbohydrate antibodies was: ASCA 69%, AMCA 32%, ACCA 28% and ALCA 24% with the highest prevalence being for ASCA (P-value<0.0001) while in patients with ulcerative colitis the prevalence was: ACCA 46%, AMCA 35%, ALCA 23% and ASCA 15% with the highest prevalence being for ACCA (P- value<0.001). Conclusion: Anticarbohydrate antibodies are significantly present in patients with IBD. The use of a panel of anticarbohydrate antibodies may provide additional help in distinguishing IBD from non-IBD disease patterns and narrow the range of differential diagnosis in these patients.

DOI

10.21608/ejhm.2018.16969

Authors

First Name

Mohammed

Last Name

Fakhraldeen

MiddleName

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Affiliation

Lecturer of internal medicine, Faculty of medicine, Mansoura University

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Orcid

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First Name

Huseen Saad

Last Name

Mostafa

MiddleName

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Affiliation

Consultant clinical pathology, King Fahd hospital, Riyadh, Saudi Arabia

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Volume

39

Article Issue

1

Related Issue

3582

Issue Date

2018-04-01

Receive Date

2018-10-19

Publish Date

2018-04-01

Page Start

260

Page End

267

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 39_Issue 1_Pages 260-267.pdf

PDF . 285.2kB

Link

https://ejhm.journals.ekb.eg/article_16969.html

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https://ejhm.journals.ekb.eg/service?article_code=16969

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Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Anticarbohydrate antibodies in patients with inflammatory bowel disease.

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Article

Created At

22 Jan 2023