Beta
ManageSearchChatDiscover
16964

Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background:Hepatocellularcarcinoma(HCC)isthefifthmostcommonmalignancyinthe world.InEgypt,HCCwasreportedtoaccountforabout4.7%ofchronicliverdisease(CLD) patients.Squamouscellcarcinomaantigen(SCCA)hasbeenreportedtobestronglyexpressed inHCCtissuehamperingitsextensiveuseinclinicalpractice. Aim:Studythevalueofserumsquamouscellcarcinomaantigen(SCCA)forscreeningof HCC. Materials&Method:Thestudycomprisedoftwogroups.GroupAincluded60patientswith HCCdiagnosticallyconfirmedbyspiralCT,elevatedalfa-fetoprotein(AFP),and/orliverbiopsy .GroupBCLDpatientsdiagnosedonclinical,laboratory,andultrasonographicalinvestigations; groupBsuclassifiedintothreecategoriesaccordingtoCHILD-PUGHscoreincluded30 patients,matchedforsexandage.Allgroupsweresubjectedtothoroughhistorytaking,full clinicalexamination,andlaboratoryinvestigationsincludingliverfunctions,viralmarkers,and AFPandSCCAestimationusingELISAtechnique. Results:ThisstudyrevealedahighlysignificantdifferencebetweenpatientswithHCCand CLDregardingserumSCCAlevelsbeinghigheringroupA(10.35±20.677)thangroup B(1.64±2.462)(p=0.02).SCCAlevelwaselevatedinpatientswithHCCwithnormalAFPlevels representingitsusefulroleinearlydetectionandfollow-upofpatientstreatedforHCC.The cut-offvaluewasestablishedat2ng/mlwithsensitivityof80%andspecificityof70%). Conclusion:SCCAcouldrepresentausefultoolasamarkerfordetectionofHCC.

DOI

10.21608/ejhm.2018.16964

Keywords

Hepatocellularcarcinoma, squamouscellcarcinomaantigen, tumormarkers

Authors

First Name

MohamedA.

Last Name

EzzelArab

MiddleName

-

Affiliation

Internal Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt

Email

-

City

-

Orcid

-

First Name

MohammadA.

Last Name

Hassanein

MiddleName

-

Affiliation

Tropical Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Hassany

MiddleName

-

Affiliation

Tropical Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt

Email

-

City

-

Orcid

-

First Name

SalahEldeenM.

Last Name

Ahmad

MiddleName

-

Affiliation

Tropical Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt

Email

-

City

-

Orcid

-

First Name

AminM.

Last Name

AbdElBaki

MiddleName

-

Affiliation

Tropical Medicine Department Department -National Hepatology And Tropical Medicine Research Institute,Cairo,Egypt

Email

-

City

-

Orcid

-

First Name

NashwaA.

Last Name

AbdEl Moniem

MiddleName

-

Affiliation

Clinical Pathology Department -National Hepatology And Tropical Medicine Research

Email

-

City

-

Orcid

-

Volume

39

Article Issue

1

Related Issue

3582

Issue Date

2018-04-01

Receive Date

2018-10-19

Publish Date

2018-04-01

Page Start

208

Page End

217

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 39_Issue 1_Pages 208-217.pdf

PDF . 1.2MB

Link

https://ejhm.journals.ekb.eg/article_16964.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16964

Order

7

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC

Details

Type

Article

Created At

22 Jan 2023