Beta
ManageSearchChatDiscover
16962

Transdermal Nitroglycerin Enhances Lidocaine And Neostigmine for Intravenous Anesthesia in Patients Undergoing Hand Surgery. A Prospective Randomized Double Blind Placebo Control

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

In a prospective randomized blind study, we investigated the effects of adding transdermal nitroglycerine for lidocaine and neostigmine for intravenous regional anesthesia in adult patients undergoing hand surgery. Patients and Methods Sixty patients (ASA grade I, aged 20-60 years) of both sexes were enrolled. The patients were randomly allocated to receive either 40ml of 0.5% lidocaine plus a transdermal placebo patch (control group n=15), 40ml of 0.5% lidocaine with 0.5mg of neostigmine plus a transdermal placebo patch (Neostigmine group, n=15), 40ml of 0.8% lidocaine plus a transdermal nitroglycerine patch (Nitroglycerine group, n=15) or 40ml of 0.5% lidocaine with 0.5mg of neostigmine plus a transdermal nitroglycerine patch (Neostigmine - Nitroglycerine group, n=15). All routine hemodynamic parameters and O2 saturation were monitored, surgical time, sensory and motor block onset times, sensory and motor block recovery times and time to first analgesic requirement were measured. Operative conditions and quality of anesthesia were also recorded. Results Sensory and motor block onset times were shorter in the neostigmine ā€“ nitroglycerine group compared with all other groups (p<0.05). Sensory block recovery time was significantly prolonged and the quality of anesthesia was better in the neostigmine ā€“ nitroglycerine group compared with all other groups (p<0.05). Conclusion We found that the addition of 0.5mg neostigmine to 40ml of 0.5% lidocaine for intravenous regional anesthesia with a 5mg transdermal nitroglycerine patch improved the operating conditions and quality of anesthesia and prolonged postoperative relief with no adverse effects.

DOI

10.21608/ejhm.2018.16962

Authors

First Name

Osama

Last Name

Farouk

MiddleName

-

Affiliation

King Abdulaziz Naval Base Hospital, Jubail, KSA.

Email

-

City

-

Orcid

-

First Name

Jamal

Last Name

Shahin

MiddleName

-

Affiliation

King Abdulaziz Naval Base Hospital, Jubail, KSA.

Email

-

City

-

Orcid

-

First Name

Amr

Last Name

Mokhtar

MiddleName

-

Affiliation

King Abdulaziz Naval Base Hospital, Jubail, KSA.

Email

-

City

-

Orcid

-

First Name

Hassan

Last Name

Abudaleh

MiddleName

-

Affiliation

Department of Anesthesia and the Department of Orthopedics

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Abdelkawy

MiddleName

-

Affiliation

Department of Anesthesia and the Department of Orthopedics

Email

-

City

-

Orcid

-

Volume

39

Article Issue

1

Related Issue

3582

Issue Date

2018-04-01

Receive Date

2018-10-19

Publish Date

2018-04-01

Page Start

189

Page End

196

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 39_Issue 1_Pages 189-196.pdf

PDF . 247.0kB

Link

https://ejhm.journals.ekb.eg/article_16962.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16962

Order

5

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Transdermal Nitroglycerin Enhances Lidocaine And Neostigmine for Intravenous Anesthesia in Patients Undergoing Hand Surgery. A Prospective Randomized Double Blind Placebo Control

Details

Type

Article

Created At

22 Jan 2023