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16959

Association of factor V Leiden mutation with deep vein thrombosis among Egyptian cases

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Last updated: 24 Dec 2024

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Abstract

Background: Deep vein thrombosis (DVT) is a blood clot in a major vein, usually in the legs and/or pelvis. If part of the thrombus breaks off, it becomes an embolism, which can travel through the heart and block the arteries to the lungs. Factor V Leiden (FVL) is a common genetic risk factor for hereditary hypercoagulability disorder in several populations. The present study investigates the association of FVL mutation with DVT among Egyptian cases. Patients & methods: The study included 44 cases (16 males and 28 females) with an age range of 20 to 80 years in addition to 211 healthy unrelated controls of matched age and sex. A multiplex allele-specific PCR amplification was conducted for assignment of FVL gene mutation (G1691A). Results: Cases having the mutant allele A (AA and AG genotypes) were significantly higher than controls (38.6% vs. 18.5%; P < 0.05, OR= 2.78 and CI 95%, 1.380–5.589).
Conclusion: These results concluded that FVL mutation has a high frequency and positive association with the occurrence of deep vein thrombosis among Egyptian cases.  

DOI

10.21608/ejhm.2018.16959

Keywords

factor V Leiden mutation, Deep Vein Thrombosis, Egyptian population

Authors

First Name

Sherif H.

Last Name

Abdeen

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Mansoura University

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City

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Orcid

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First Name

Rizk

Last Name

El-Baz

MiddleName

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Affiliation

Genetics Unit, Faculty of Medicine, Mansoura University

Email

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City

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Orcid

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First Name

Ahmad

Last Name

Settin

MiddleName

-

Affiliation

Genetics Unit, Faculty of Medicine, Mansoura University

Email

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City

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Orcid

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First Name

Wessam

Last Name

El-Gazar

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Mansoura University

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-

City

-

Orcid

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Volume

39

Article Issue

1

Related Issue

3582

Issue Date

2018-04-01

Receive Date

2018-10-19

Publish Date

2018-04-01

Page Start

154

Page End

163

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 39_Issue 1_Pages 154-163.pdf

PDF . 328.2kB

Link

https://ejhm.journals.ekb.eg/article_16959.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16959

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Association of factor V Leiden mutation with deep vein thrombosis among Egyptian cases

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Article

Created At

22 Jan 2023