Beta
ManageSearchChatDiscover
16957

Neutrophil CD64 in diagnosis of infection in systemic lupus erythematosus patients

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Infection is one of the major complications as well as cause of death in systemic lupus erythematosus patients (SLE). Differentiation between early infection and disease flare in these patients is often clinically difficult because both have similar signs and symptoms. Aim: To evaluate CD64 expression on neutrophils as an early marker that can discriminate between infection and disease flare in SLE patients. Also, its clinical utility in comparison with traditional laboratory tests used for detecting infection will be studied. Methods: The study included 38 subjects; 10 apparently healthy individuals as healthy controls and 28 SLE patients divided into three groups (10 SLE patients with infection, 10 SLE patients with flare and 8 SLE patients without infection or flare). CD64 on neutrophils was measured using flow cytometry. Total leucocytic count, erythrocyte sedimentation rate and high-sensitive C-reactive protein were also measured. Results: The median of the percentage of neutrophils expressing CD64 was higher in all SLE patients compared to normal control. It was significantly higher in SLE patients with infection than those with disease activity (P <0.001). Using a cutoff value of ≥17.6, % of neutrophils expressing CD64; it revealed 100% sensitivity and 100% specificity. Conclusion: The results of the present work showed that measurement of CD64 expression on neutrophils could be used as a sensitive and specific marker for detection of infection in SLE patients and differentiation between infection and disease activity.  

DOI

10.21608/ejhm.2010.16957

Keywords

Systemic lupus erythematosus, CD64, Infection

Authors

First Name

Enas E.

Last Name

El-Said

MiddleName

-

Affiliation

Clinical Pathology department Faculty of medicine for girls, Al-Azhar university

Email

-

City

-

Orcid

-

First Name

Salwa R.

Last Name

Ali

MiddleName

-

Affiliation

Internal medicine department, Faculty of medicine for girls, Al-Azhar university

Email

-

City

-

Orcid

-

First Name

Fawzia A.

Last Name

El-Sheshtawy

MiddleName

-

Affiliation

Clinical Pathology department Faculty of medicine for girls, Al-Azhar university

Email

-

City

-

Orcid

-

Volume

41

Article Issue

1

Related Issue

3581

Issue Date

2010-10-01

Receive Date

2018-10-19

Publish Date

2010-10-01

Page Start

600

Page End

617

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 41_Issue 1_Pages 600-617.pdf

PDF . 473.2kB

Link

https://ejhm.journals.ekb.eg/article_16957.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16957

Order

12

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Neutrophil CD64 in diagnosis of infection in systemic lupus erythematosus patients

Details

Type

Article

Created At

22 Jan 2023