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16955

Effect of crowding stress and /or sulpiride treatment on some physiological and histological parameters in female albino rats.

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Last updated: 03 Jan 2025

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Abstract

Background: Crowding is the most stressful factor on human being. So these studies aimed to clarify effect on some physiological and histological parameters. Material and methods: 36 Female rats were divided into four groups (6/each):1-control, 2- treated with sulpiride drug,3- crowded exposure 4- crowded + drug . Results: drug recorded a significant increase only in the percentage of body weight gain but the other parameters showed no significant changes. Stress recorded a significant increase in glucose, ALT, GGT, TP, globulin, creatinine, total lipids, TG, cholesterol, HDL-C, LDL-C. A significant decrease in percentage of body weight gain and A/G ratio were also detected. Sulpiride drug ameliorated most of these parameters. Concerning the histological and histochemical studies sulpiride treatment showed no detectable changes in the kidney and liver tissues with exception of increased lymphocytes. Exposure to crowding showed many dystrophic changes in both tissue , but drug treatment improved all the previous changes and this indicates the protective effect of sulpiride against crowding exposure. Conclusion: it is useful to use sulpiride drug in people who exposed to crowded stress.

DOI

10.21608/ejhm.2010.16955

Keywords

crowding, Sulpiride drug, albino rats, physiological parameters, Histopathology and histochemistery

Authors

First Name

Fatma

Last Name

Eid

MiddleName

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Affiliation

Zoology Department ,Faculty of Science,Al-Azhar University. (Histology)

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Orcid

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First Name

Eman G.E.

Last Name

Helal

MiddleName

-

Affiliation

Zoology Department ,Faculty of Science,Al-Azhar University. (Physiology)

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Orcid

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First Name

Neama M.

Last Name

Taha

MiddleName

-

Affiliation

Zoology Department ,Faculty of Science,Al-Azhar University. (Physiology)

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Orcid

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Volume

41

Article Issue

1

Related Issue

3581

Issue Date

2010-10-01

Receive Date

2018-10-19

Publish Date

2010-10-01

Page Start

566

Page End

589

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 41_Issue 1_Pages 566-589.pdf

PDF . 1.9MB

Link

https://ejhm.journals.ekb.eg/article_16955.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16955

Order

10

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of crowding stress and /or sulpiride treatment on some physiological and histological parameters in female albino rats.

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Article

Created At

22 Jan 2023