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16953

Relationship between HCV infection and Insulin resistance in non-obese non- diabetic patients

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Last updated: 24 Dec 2024

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Abstract

Background:HepatitisCisamajorcauseofliver-relatedmorbidityandmortalityandrepresentsa majorpublichealthprobleminEgyptandworldwide.Thereisgrowingevidenceasregardtothe associationbetweenhepatitisCvirus(HCV)infectionandtype2diabetesmellitus.However,the mutuallinkandrelatedvirologicalimplicationhavenotbeenfullyclarified.Insulinresistance(IR) playsaprimaryroleinthedevelopmentoftype2DM.Thisissupportedbytheresultsofprospective longitudinalstudiesshowingthatIRisthebestpredictorofthedevelopmentoftype2DM,preceding itsonsetby10-20years.
Aim:ToassessthecorrelationbetweenHCVmorbidityandInsulinresistance(IR)detectedby HOMAtestinnonediabeticnoneobeseHCVpatients
Materials&Method:Thestudyparticipantsweresubcategorizedintotwogroups,Group(I): included867healthysubjects(negativeHCVRNA)asacontrolgroup.Group(II):included277 patientswithchronicHCVasastudygroup.The2groupsweresubjectedtothoroughhistorytaking, fullclinicalexamination,Anthropometricstudy,ultrasonographicexaminationandlaboratory investigationsincludingliverfunctions,viralmarkers,andqualitativePCRforHCVRNA,lipid profile,glucoseprofileandHOMAtest.
Results:ThisstudyrevealedhigherinsulinresistanceintheHCVstudygroupthanthecontrolgroup.

DOI

10.21608/ejhm.2010.16953

Keywords

HCV-Insulinresistance, HOMA test

Authors

First Name

Mostafa K.

Last Name

Mohamed

MiddleName

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Affiliation

Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain Shams University.

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Orcid

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First Name

Gamal

Last Name

Esmat

MiddleName

-

Affiliation

Department of Tropical Medicine, Cairo University

Email

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City

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Orcid

-

First Name

Mohamed

Last Name

Said

MiddleName

-

Affiliation

Department of Tropical Medicine, Cairo University

Email

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City

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Orcid

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First Name

Mohamed

Last Name

Abdel Hamid

MiddleName

-

Affiliation

Viral Hepatitis Research Laboratory, National Hepatology and Tropical Medicine Research Institute

Email

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City

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Orcid

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First Name

Mohamed

Last Name

Hassany

MiddleName

-

Affiliation

Department of Tropical Medicine, National Hepatology and Tropical Medicine Research Institute.

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City

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Orcid

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First Name

Mohamad A.

Last Name

Hassanein

MiddleName

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Affiliation

Department of Tropical Medicine, National Hepatology and Tropical Medicine Research Institute.

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City

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Orcid

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First Name

Kamal A.

Last Name

El- Atrebi

MiddleName

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Affiliation

Department of Tropical Medicine, National Hepatology and Tropical Medicine Research Institute.

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City

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Orcid

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First Name

Helmy

Last Name

El Gazzar

MiddleName

-

Affiliation

Department of Clinical pathology, Hearing and Speech Institute, Egypt.

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City

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Orcid

-

First Name

M S.

Last Name

Omar

MiddleName

-

Affiliation

Department of Clinical pathology, Faculty of Medicine, Bani Sewif University.

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Orcid

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Volume

41

Article Issue

1

Related Issue

3581

Issue Date

2010-10-01

Receive Date

2018-10-19

Publish Date

2010-10-01

Page Start

540

Page End

550

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 41_Issue 1_Pages 540-550.pdf

PDF . 1.6MB

Link

https://ejhm.journals.ekb.eg/article_16953.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16953

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Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Relationship between HCV infection and Insulin resistance in non-obese non- diabetic patients

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Article

Created At

22 Jan 2023