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16947

Biochemical, histological and histochemical studies of oat (Avena sativa) on hyperlipidemic rats.

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Last updated: 03 Jan 2025

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Abstract

Hyperlipidemia : is an elevation of lipids in the blood stream and these lipids include: fats, fatty acids, cholesterol, cholesterol esters, phospholipids, and triglycerides. Hyperlipidemia is associated with hepatic fat accumulation .
Material and methods:
Six groups (5rat/group) of female albino (Rattus albinus) were used. The 1st group used as control, in the 2nd group hyperlipidemia (25% fat & 2% cholesterol) was induced for 3 weeks only then sacrified , the 3rd group was hyperlipidemic rats for 3 weeks then left other 3 weeks without any additional treatment as a recovery period, the 4th group served as hyperlipidemic group for 3 weeks then treated with Avena sativa for another 3 weeks ( 200 g/Kg diet ), the 5th group was hyperlipidemic (25% fat & 2% cholesterol) for 6 weeks and the 6th group served as hyperlipidemic rats for 6 weeks, and at the same time given Avena sativa in diet (200 g/Kg diet). Results:
The biochemical parameters showed highly significant increase in body weight, serum glucose, AST, ALT, GGT, LDH, urea, creatinine, total protein, albumin, total lipids, cholesterol, triglycerides and LDL-cholesterol, while there was highly significant decrease in HDL- cholesterol.Many histopathological and histochemical changes were detected in liver tissue of the hyperlipidemic rats. Meanwhile, the treatment with oat ameliorated the biochemical parameters, histological and histochemical results
Conclusion:
It is recommend to use oat in diets for hyperlipidemic patients or those people who have hyperlipidemic family history.

DOI

10.21608/ejhm.2010.16947

Keywords

hyperlipidemia, oat bran, Lipid profile, albino rats, physiological parameters, histopathology and histochemistry

Authors

First Name

Eman G.E.

Last Name

Helal

MiddleName

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Affiliation

Zoology Department(physiology), Faculty of Science, Al- Azhar University

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Orcid

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First Name

Amira M.

Last Name

Salah EL-Din

MiddleName

-

Affiliation

Zoology Department(physiology), Faculty of Science, Al- Azhar University

Email

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City

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Orcid

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First Name

Fatma

Last Name

Eid

MiddleName

-

Affiliation

Zoology Department(histology), Faculty of Science, Al- Azhar University

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Orcid

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Volume

41

Article Issue

1

Related Issue

3581

Issue Date

2010-10-01

Receive Date

2018-10-19

Publish Date

2010-10-01

Page Start

470

Page End

490

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 41_Issue 1_Pages 470-490.pdf

PDF . 2.7MB

Link

https://ejhm.journals.ekb.eg/article_16947.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16947

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Biochemical, histological and histochemical studies of oat (Avena sativa) on hyperlipidemic rats.

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Article

Created At

22 Jan 2023