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16946

Ultrastructure alterations of retinal photoreceptors of the black rat, Rattus rattus exposed to certain heavy metals

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Last updated: 03 Jan 2025

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Abstract

Aim of work: This study was designed to investigate the impact of lead and cadmium on the retinal photoreceptors of rats. Material &Methods: Adult black rats, Rattus rattus, were selected and divided into control and exposed groups. The exposed group was housed in industrial car batteries room containing fumes of lead and cadmium. The retina prepared for scanning and transmission electron microscopy. Results: The scanning electron microscopy revealed different lead-cadmium changes represented by gradual increasing in spaces between segments of the photoreceptors, associated with swelling of their inner segments and accompanied with rupture, degeneration and decreased numbers of some rods and cones in the outer segments. Disorganization, shortening, a decrease in number of the photoreceptors and a great deformity were the characteristic changes after prolonged exposure to the heavy metals. The aforementioned damages of the photoreceptors were confirmed at the ultrastructural level using transmission electron microscope in the form of progressive disorganization, shortening, swelling, widening of the intradiscal spaces, vacuolization and degeneration of the lamellae of the outer segments (OS), followed by the damage of mitochondria of the inner segments(IS). Excessive penetration of the processes of the pigmented epithelium (PE) filled with pigments of different shapes and sizes between the damaged segments were noted. These pathological changes were considered the first symptoms in the retinal toxicity. Conclusion: The present results are alarming and call for further investigations to elucidate the impact of exposure to these heavy metals for longer periods on the rat vision and eye structure.  

DOI

10.21608/ejhm.2010.16946

Keywords

Photoreceptors, SEM, TEM, Heavy metals, Rats

Authors

First Name

Elsayed F. A.

Last Name

El-Dawi

MiddleName

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Affiliation

Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt

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Orcid

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First Name

Naima I.

Last Name

Naguib

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Affiliation

Health Radiation Research Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

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Volume

41

Article Issue

1

Related Issue

3581

Issue Date

2010-10-01

Receive Date

2018-10-19

Publish Date

2010-10-01

Page Start

456

Page End

469

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 41_Issue 1_Pages 456-469.pdf

PDF . 1.5MB

Link

https://ejhm.journals.ekb.eg/article_16946.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16946

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Ultrastructure alterations of retinal photoreceptors of the black rat, Rattus rattus exposed to certain heavy metals

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Article

Created At

22 Jan 2023