Hyperlipidemia (mainly increased level of total cholesterol (TC), triglycerides (TG) and low-density lipoprotein(LDL) cholesterol with a decrease in high-density lipoprotein(HDL)- cholesterol) is the predictor of coronary artery disease (CAD). Hyperlipidemia is an important risk factor in the initiation and progression of atherosclerotic impasse.   Aim of the work: Many people have fast food that contains large amount of lipids and leads to the formation of free radicals which cause hyperlipidemia. The present study demonstrate the effect of the fennel (Foeniculum vulgare) in the treatment of hyperlipidemia.   Material and methods: Six groups (5rat/group) of female albino rats (Rattus albinus) were used. The 1^st group used as control, in the 2^nd group hyperlipidemia (25% fat and 2% cholesterol) was induced for 3 weeks only then sacrified , the 3^rd group was hyperlipidemic rats for 3 weeks then left for a further 3 weeks without any additional treatment as a recovery period, the 4^th group served as hyperlipidemic group for 3 weeks then treated with Foeniculum vulgare for  another 3 weeks (10 mg/100 gm b. wt.), the 5^th group was hyperlipidemic (25% fat and 2% cholesterol) for 6 weeks and the 6^th group served as hyperlipidemic rats for 6 weeks, and at the same time given Foeniculum vulgare (10 mg/100 gm b. wt.) by oral administration.   Results: The biochemical parameters showed highly significant increase in the body weight, serum glucose, ASAT, ALAT, GGT, LDH, total protein, albumin and total lipids in liver .Many histopathological and histochemical changes were detected in liver tissue of the hyperlipidemic rats. Meanwhile, the treatment with fennel ameliorated the biochemical parameters, histological and histochemical results.   Conclusion: It is recommend to use fennel in diets for hyperlipidemic patients or those people who have hyperlipidemic family history.   Hyperlipidemia (mainly increased level of total cholesterol (TC), triglycerides (TG) and low-density lipoprotein(LDL) cholesterol with a decrease in high-density lipoprotein(HDL)- cholesterol) is the predictor of coronary artery disease (CAD). Hyperlipidemia is an important risk factor in the initiation and progression of atherosclerotic impasse.   Aim of the work: Many people have fast food that contains large amount of lipids and leads to the formation of free radicals which cause hyperlipidemia. The present study demonstrate the effect of the fennel (Foeniculum vulgare) in the treatment of hyperlipidemia.   Material and methods: Six groups (5rat/group) of female albino rats (Rattus albinus) were used. The 1^st group used as control, in the 2^nd group hyperlipidemia (25% fat and 2% cholesterol) was induced for 3 weeks only then sacrified , the 3^rd group was hyperlipidemic rats for 3 weeks then left for a further 3 weeks without any additional treatment as a recovery period, the 4^th group served as hyperlipidemic group for 3 weeks then treated with Foeniculum vulgare for  another 3 weeks (10 mg/100 gm b. wt.), the 5^th group was hyperlipidemic (25% fat and 2% cholesterol) for 6 weeks and the 6^th group served as hyperlipidemic rats for 6 weeks, and at the same time given Foeniculum vulgare (10 mg/100 gm b. wt.) by oral administration.   Results: The biochemical parameters showed highly significant increase in the body weight, serum glucose, ASAT, ALAT, GGT, LDH, total protein, albumin and total lipids in liver .Many histopathological and histochemical changes were detected in liver tissue of the hyperlipidemic rats. Meanwhile, the treatment with fennel ameliorated the biochemical parameters, histological and histochemical results.   Conclusion: It is recommend to use fennel in diets for hyperlipidemic patients or those people who have hyperlipidemic family history.