Background: The present study aimed to investigate the dynamics of immunoregulatory factors implicated in the murine model of soluble adult worm antigen preparation (SWAP)and UV-irradiated adult worm extract-induced granulomatous hypo-responsivness.
 
Material and Methods: Native male mice were classified into four groups. The first negative control (non-infected) group, the second positive control (infected) group, the third SWAP-vaccinated group and the fourth UV-irradiated adult worm extract-vaccinated group. The last two groups were injected subcutaneous by 0.2 ml (contained 100 µg protein) of the two used vaccines SWAP or UV-irradiated adult worm extract respectively, four weeks prior to infection. The 2^nd, 3^rd and 4^th mice groups were infected by subcutaneous injection with 100 cercariae of Egyptian strain of S. mansoni. All mice groups were sacrificed 8 weeks post-infection.
 
Results:Parasitological parameters such as worms count, eggs/gram tissues of liver and intestine were studied. Biochemical parameters such as the activities of liver function tests (AST, ALT, ALP and γGT) were measured. The cellular immune responses were assessed by studying the cytokine measurement. Hepatic histopathological criteria and the morphological changes of adult worms were studied through the scanning electron microscope.
 
Conclusion: The present results revealed  that the UV-irradiated adult worm extract have high efficacy than SWAP as immunizing antigens as shows in our data, which reported that irradiation associated vaccine antigen was shown to achieve a higher protection in mice.