Osteoporosis is a metabolic bone disease characterized by bone remodeling .This study was done for the detection of some blood and urine markers in cases of osteoporosis among Egyptian women at different ages .The study included 100 women divided into three groups. The first group included 33 women their ages ranged between 35-45 years old, the second included 33 women their ages ranged between 45-55 years old and the third group included 34 women their ages were above 55 years old. Fore all subjects DEXA densitometry was performed. Serum calcium, phosphorous, alkaline phosphatase, Osteocalcin and urinary hydroxyproline, deoxypyridinoline and creatinine were estimated. Results:  In osteopenic and osteoporotic women there was elevation in serum alkaline phosphatase and osteocalcin and in urinary pyridinoline and hydroxyproline, while there was decrease in serum calcium .Conclusion: The Egyptian women subjected to the study were suffering from osteopenia from the age of 35 years old or may be earlier Above the age of 55 (postmenopausal) it was found that 50% of women were osteopenic and osteoporotic.