Background: Noise is the most stressful factor and human being. So these studies aim to clarify its effect on some physiological and histological parameters.     Material and methods: 24 Female rats were divided into four groups (6/each):1-control, 2-treated with sulpiride drug,3- noise exposure (90db/3h per day for 30days), 4-noise + drug   Results: drug recorded a significant  increase only in the percentage of   body weight gain but the other parameters  showed no significant changes. Noise stress recorded a significant increase in glucose, ALT, GGT, TP, globulin. A significant decrease in percentage of body weight gain and A/G ratio were also detected . It has been detected that Sulpiride drug ameliorated most of these parameters.  Concerning the histological and histochemical studies sulpiride treatment showed no detectable changes in the liver tissues with exception of increased lymphocytes. Exposure to noise showed many dystrophic change in tissue, but drug treatment improved all the  previous changes and this indicates the protective effect of sulpiride against noise  exposure.         Conclusion: it is useful to use sulpiride drug in people who expose to noise stress.