Background: Noise is the most stressful factor for experimental animals. So these studies aim to clarify its effect on some physiological and histological parameters.     Material and methods: 36 Female rats were divided into four groups (6/each):1-control, 2-treated with sulpiride drug,3- noise exposure (90db/3h per day for 30days), 4-noise + drug   Results: drug recorded no significant change   in all the studied  parameters. Noise stress recorded a significant increase in creatinine, total lipids, TG, Cholesterol, HDL-C, LDL-C and no significant changes in urea, uric acide. It has been detected that  sulpiride drug ameliorated most of these parameters.Concerning the histological and histochemical studies sulpiride treatment showed no detectable changes in  the kidney tissue with exception of increased lymphocytes. Exposure to noise showed many dystrophic changes in the kidney tissue, but drug treatment improved all the previous changes and this indicates the protective effect of sulpiride against noise exposure.         Conclusion: It is useful to use sulpiride drug in people who exposed to noise stress.