Background & Aims: Curcumin (CCM), Cinnamon (CNN) and Ginger (GE) had been considered to possess antioxidant activities. This study aimed to investigate their protection effect against trichloroethylene (TCE)-induced hepatotoxicity and to demonstrate its possible mode of action.   Methods: Rats were fed CCM, CNN and GE singly with or without 5mg/l of TCE in drinking water. The rat were killed after treatment period of 8 weeks, and the serum levels of alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), bilirubin, proteins, glucose, albumin and triglycerides were determined.   Results: TCE- receiving rat exhibited significant changes in biomarkers of liver function to indicate liver injury. The CCM containing diet significantly ameliorated the serum aminotransferases, especially ALAT, total protein and albumin. The CNN containing diet significantly ameliorated the total protein and albumin. The GE containing diet significantly ameliorated the serum aminotransferases, especially ALAT. In conclusion, this work indicated that CCM is the most herbal plant which can protected and alleviated the liver function.