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16939

Role of Prophylactic Tranexamic Acid in Reducing Blood loss during Elective Caesarean section in Rural Area

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Last updated: 03 Jan 2025

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Abstract

Background: To reduce maternal mortality and morbidity caused by bleeding, it is important to reduce the amount of bleeding during and after lower segment caesarean section (LSCS). Tranexamic acid helps to reduce bleeding during and after Caesarean section. Aim of the Work: To analyse the effectiveness of Tranexamic Acid (TXA) in reducing blood loss during elective caesarean section. Patients and Methods: The current study was conducted as a double blinded, randomized, controlled trial on 300 women recruited from labor ward in Kafr Elsheikh General Hospital whom planned to have scheduled casaerean section. A total number of 150 patients received tranexamic acid before induction of anesthesia in addition to oxytocin after delivery of the baby; the other 150 patients received oxytocin only. Results: In the current study, no significant difference between study and control groups as regards age (p 0.374). In the current study, no significant difference between study and control groups as regards gestational age (p 0.335). In the current study, number of soaked towels and amount of blood in suction set, which reflect the volume of blood loss from placental delivery to the end of surgery was significantly lower in study group than control group. In the current study, no significant difference between study and control groups as regards preoperative hemoglobin (p 0.614). Postoperative hemoglobin was significantly higher in study group than control group (p<0.004). Reduction in hemoglobin was significantly less in study group than control group (p<0.001). In the current study, no significant difference between study and control groups as regards preoperative hematocrit (p 0.527). Postoperative hematocrit was significantly higher in study group than control group (p0.17), Reduction in Hematocrit was significantly less in study group than in control group (p<0.001). In the current study, need to iron replacement or blood transfusion was significantly less frequent in study group than in control group (p<0.031). Conclusion: The use of tranexamic acid prior to cesarean section is significantly effective in reducing blood loss during caesarean section with no observed maternal or neonatal side effects. Recommendations: Further studies are needed to assess possibility of use of tranexamic acid for treatment of postpartum hemorrhage.

DOI

10.21608/ejhm.2018.16939

Keywords

prophylactic tranexamic acid, blood loss, Elective cesarean section

Authors

First Name

Hossam Elden H.

Last Name

Kamel

MiddleName

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Affiliation

Department of Obstetrics & Gynecology, Faculty of Medicine – Al-Azhar University

Email

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City

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Orcid

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First Name

AbdAlsattar M.

Last Name

Farhan

MiddleName

-

Affiliation

Department of Obstetrics & Gynecology, Faculty of Medicine – Al-Azhar University

Email

-

City

-

Orcid

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First Name

Hesham F.

Last Name

Abou Senna

MiddleName

-

Affiliation

Department of Obstetrics & Gynecology, Faculty of Medicine – Al-Azhar University

Email

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City

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Orcid

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First Name

Mohammed A.

Last Name

Khedr

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine – Al-Azhar University

Email

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City

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Orcid

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First Name

Ahmed A.

Last Name

Albhairy

MiddleName

-

Affiliation

Department of Obstetrics & Gynecology, Faculty of Medicine – Al-Azhar University

Email

daelbhery@gmail.com

City

-

Orcid

-

Volume

73

Article Issue

6

Related Issue

3486

Issue Date

2018-10-01

Receive Date

2018-10-19

Publish Date

2018-10-01

Page Start

6,886

Page End

6,896

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 73_Issue 6_Pages 6886-6896.pdf

PDF . 418.6kB

Link

https://ejhm.journals.ekb.eg/article_16939.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16939

Order

14

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of Prophylactic Tranexamic Acid in Reducing Blood loss during Elective Caesarean section in Rural Area

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Article

Created At

22 Jan 2023