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16936

Effect of lipid-lowering therapy on the mortality among patients with coronary heart diseases: A systematic review

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Last updated: 03 Jan 2025

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Abstract

Introduction: Studies supported the use of lipid lowering therapy such as statin as a treatment of hypercholesterolemia for prevention of CHD. However, the use of lipid lowering therapy is not well established in clinical practice due to lack of robust evidence and contra-indications in patients with heart failure (HF). This review aimed at evaluating the evidence about preventive effect of lipid lowering therapy on the mortality caused by coronary heart diseases. Methods: A comprehensive electronic search was carried out using MEDLINE, EMBASE, Cochrane databases to identify articles which aimed at assessing the preventive effect of lipid lowering therapy for coronary heart diseases. The data were collected from included studies using data collection sheets using specific items such as mean patient age, type of coronary disease, mean duration of the disease, drugs of lipid lowering therapy, regime of lipid lowering therapy, duration of lipid lowering therapy, reduction in mortality rate, and associated side effects. Results: Following evaluation of the eligible articles, 11 articles were included with randomized controlled trials investigating the effect of lipid-lowering therapy on the mortality of patient suffering from coronary heart diseases. The sample size in the included studies ranged from 106 to 10355 participants, and the total number of participants among all included studies were 50830 with mean age ranging from 31 to 82 years old. Conclusions: Despite the overall good outcome that is attributed to the use of statins that is not clear weather this benefit is credited to its anti- inflammatory or direct LDL lowering effect.  

DOI

10.21608/ejhm.2018.16936

Keywords

Lipid, Therapy, Statin, Heart failure, myocardial infarction

Authors

First Name

Abdullah Talal

Last Name

Almaghrabi

MiddleName

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Affiliation

University of Debrecen

Email

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City

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Orcid

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First Name

Waleed Mohammed

Last Name

Alghamdi

MiddleName

-

Affiliation

University of Debrecen

Email

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City

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Orcid

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First Name

Salah Mohammed

Last Name

Almuyidi

MiddleName

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Affiliation

FacultyofMedicine,TaifUniversity

Email

-

City

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Orcid

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First Name

Hadil Hilal

Last Name

Abuzaid

MiddleName

-

Affiliation

AppliedSciencePrivate University

Email

-

City

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Orcid

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Volume

73

Article Issue

6

Related Issue

3486

Issue Date

2018-10-01

Receive Date

2018-10-19

Publish Date

2018-10-01

Page Start

6,864

Page End

6,869

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 73_Issue 6_Pages 6864-6869.pdf

PDF . 572.3kB

Link

https://ejhm.journals.ekb.eg/article_16936.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16936

Order

11

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of lipid-lowering therapy on the mortality among patients with coronary heart diseases: A systematic review

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Article

Created At

22 Jan 2023