Objectives: A peptic ulcer is a common problem that occurred because of H. pylori infection and the use of nonsteroidal anti-inflammatory drugs. Epigastric pain is the most common symptom. It is characterized by burning sensation occur after meals. This study was conducted to assess peptic ulcer among patient with ischemic heart disease at TAIF city. Methods: We conducted a cross sectional study on 426 ischemic heart disease patients. The data were collected through interview with the patients and self-report questionnaire which include a set of socio-demographic variables (gender, age, sex, weight, city, smoking, drinking tea and coffee) and clinical variables (systolic, diastolic, pulse, respiratory rate, oxygen saturation) in 1/8/2017 to 17/9/2017 and approved by  King Faisal medical complex in Taif city.  Both genders above 40 years were included and excluded patients below them and patients without ischemic heart disease. Statistical analysis was performed using SPSS. Results: Of the 426 ischemic heart disease patients at TAIF city who were investigated, 229 (53.8%) were female and 197 (46.2) were male. The mean age was 64.5 years (SD=12), ranging from 25 to 100 years. As for BMI, 297(69.7%) had overweight and obese. The mean systolic was 143.49 (SD=22.9). The mean diastolic was 76.31. In total, 24.2% of patients were classified as Peptic ulcer and 75.8% had Non-Peptic ulcer symptoms. No statistical significance was found between the mean of Non-Peptic ulcer and Peptic ulcer patients in terms of oxygen saturation, systolic, diastolic, age, pulse and respiratory rate. A significant statistical relation was found for City that they lived in (P=.027), type of oils that he/she use it for cooking at home (P=.008), stress (P=0.002) and sex (P=.032) for Non-Peptic ulcer symptoms and Peptic ulcer symptoms. Conclusion: This study demonstrated a low prevalence of peptic ulcer among ischemic heart disease patients at TAIF city. Insomnia was associated with gender, type of oil, stress and city that they lived in but no significant association with BMI, taking aspirin, doing exercise and smoking.