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16245

Effect of Grape Seed Extract on Oxidative Damages in Gamma Irradiated Rats

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Last updated: 24 Dec 2024

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Abstract

Back ground: Ionizing radiation is known to produce deleterious effects in the living organisms.  Aim of the work: The aim of this study is to evaluate the possible protective effect of the chemical constituents of grape seed extract on oxidative stress induced by gamma rays.  Materials & Methods: Rats were subjected to 8 Gy fractionated doses of gamma radiation, grape seed extract 100 mg/kg body weights were daily administrated before and within radiation exposure.All parameters were investigated at 1st and 14th days post last radiation exposure. Results: The results revealed that administration of grape seed extract to irradiated rats significantly ameliorates the changes induced in antioxidant system. TBARS (lipid peroxidation index) were significantly decreased when compared with their equivalent values in irradiated rats.  In conclusion, the administration of grape seed extract to irradiated rats might provide substantial protection against oxidative damages due to its free radical scavenging and antioxidant properties of its ingredients. It could be suggested that, grape seed extract may have a potential benefits to people receiving radiotherapy.  

DOI

10.21608/ejhm.2012.16245

Keywords

Grape seed extract, γ-irradiation, Oxidative Stress, mitochondria, and Antioxidant Enzymes

Authors

First Name

Abdelgawad.A.

Last Name

Fahmi

MiddleName

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Affiliation

Chemistry Department, Faculty of Science, Cairo university

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Orcid

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First Name

M.A.

Last Name

El- Desouky

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Cairo university

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Orcid

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First Name

Neama M.

Last Name

El-Fatih

MiddleName

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Affiliation

Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Cairo, Egypt

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Orcid

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First Name

Wissam.A.

Last Name

Mohamed

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Cairo university

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-

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Orcid

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Volume

48

Article Issue

1

Related Issue

3478

Issue Date

2012-07-01

Receive Date

2018-10-09

Publish Date

2012-07-01

Page Start

414

Page End

428

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_16245.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=16245

Order

8

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of Grape Seed Extract on Oxidative Damages in Gamma Irradiated Rats

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Article

Created At

22 Jan 2023