We described the role of multi detector computerized tomography in the detection and exclusion of coronary in-stent re-stenosis compared with the conventional coronary angiography.  PATIENTS AND METHODS: 30 patients pretreated with coronary stenting and complaining of angina like symptoms underwent dual source coronary angiography one day before performing conventional coronary angiography.  RESULTS: 47 stents were examined 43 of them were assessable by DSCT-CA and the calculated sensitivity, specificity, negative predictive value, positive predictive value and overall accuracy of all assessable stents were 100%, 90%, 100%, 81% and 93%, respectively. When analyzing the results for stents ≤2.75mm in diameters the results were less encouraging, The calculated sensitivity, specificity, negative predictive value, positive predictive value and overall accuracy of all assessable stents were 100%, 70%, 100%, 40% and 75%, respectively. CONCLUSION: With the high sensitivity and negative predictive value -reaching up to 100%- with dual source CT scanners, it could be used confidently to rule out in-stent re-stenosis. However, due to the frequent false positive results, careful patient selection should be done.