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The Role of Bee Venom in Controlling Albino Rats Fetal Morphometric and Morphological Changes by Carbimazole Induced Hypothyroidism

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Last updated: 03 Jan 2025

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Abstract

Aim of the work. The present study was planned to investigate the role played by Bee venom in improving the morphometric and morphological changes induced by carbimazole in pregnant albino rats and their embryos.  Materials and method .A total number of 60 mature virgin female and 30 male Wistar wistar albino rats (for fertilization) were used in this study.Pregnancy was ascertained by vaginal smears.The experimental animals were divided into the following groups: І- (Normal group): in this group the pregnant rats were injected intraperitonealy by distilled water (The solvent of both carbimazole and bee venom) by dose 1ml/200g.body weight, from day 1 to day 18 of gestation. II-The group of treated animals: this group was divided into 3 subgroups: 1-The carbimazole group: this group was divided into2 subgroups, the pregnant rats were orally injected at a dose 2 and 3mg /200g.body weight, daily from day 1 to day 18 of gestation. 2-The Bee venom group: the pregnant rats were intraperitonealy injected with a dose 0.6 mg/200g. body weight on days 2,3,4,7,8,9,10,11,12,15 and 16 of gestation.            3-The treatment group: the pregnant rats were intraperitonealy injected with Bee venom at a dose 0.6 mg/200g. body weight 1 hour after the intraperitonealy injection by the 2 doses of carbimazole (2 and 3mg /200g. body weight).The days of injection for both treatments (Bee venom and carbimazole) were  as mentioned before. Results. The results of the present study showed thatcarbimazole treatment with its 2 doses induced highly significant increase in the body weights of pregnant rats, highly significant reduction of the  uterus weight with shortness of the horns as well as unequal distribution of the embryos between them, increased  number of the resorbed fetuses when comparing with the control group, Bee venom injection revealed  improvement of  these changes .The  orally injection of the 2 doses of carbimazole resulted in very highly decrease in fetuses body weights and lengths; however Bee venom induced obvious improvement as compared with the carbimazole effects. Orally injection of carbimazole at the dose 3mg /200g body weight showed increased fetal mortality rate as compared with the control group; however, intraperitonealy injection of Bee venom resulted in improvement in the rate of live fetuses and never of dead ones was observed after Bee venom treatment. The 2 doses of carbimazole induced  lots of  malformations of embryos such as variations in the size of embryos of the same mother, the embryos exhibited  fragile skin, sub dermal blood coagulation beside edema in different regions of the  fetal body ,as well as malformations of the regions of the eye resembled in  exophthalmos and rostrum region such as cleft lips, beside  clubbed fore and hind limbs , kyphosis of the body of the embryos, exencephaly.Bee venom treatment resulted in control  of the changes induced by carbimazole injection. The fetuses were resembled to those of the control group. Conclusion: It is clear that bee venom plays an important role in controlling the morphometric and morphological changesin fetuses of albino rats suffering from hypothyroidism induced by carbimazole ٠  

DOI

10.21608/ejhm.2013.15991

Keywords

Carbimazole, Thyroid gland, Bee venom. Pregnant Rats, fetuses

Authors

First Name

Abu Gabal

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Affiliation

College of Science and Humanity Studies, Salman Bin Abdul Aziz University

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Orcid

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First Name

Moamena

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Affiliation

College of Science, Princess Nora Bent Abdul Rahman University.

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First Name

Al Moalla

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Affiliation

College of Science, Princess Nora Bent Abdul Rahman University.

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Volume

51

Article Issue

1

Related Issue

3435

Issue Date

2013-04-01

Receive Date

2018-10-05

Publish Date

2013-04-01

Page Start

405

Page End

421

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_15991.html

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https://ejhm.journals.ekb.eg/service?article_code=15991

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23

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Role of Bee Venom in Controlling Albino Rats Fetal Morphometric and Morphological Changes by Carbimazole Induced Hypothyroidism

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Article

Created At

22 Jan 2023