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15983

Association of A Novel Adipokine With Insulin Resistance And Disease Severity in HCV Infected Patients

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Last updated: 24 Dec 2024

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Abstract

Retinol-binding protein 4 (RBP4) has been identified as a protein contributing to insulin resistance (IR). As insulin resistance is present in nearly all patients with liver cirrhosis, we evaluated RBP4 in patients with chronic hepatitis C virus infected patients (CHC). This study aimed to evaluate the role of serum retinol binding protein 4 (RBP-4) as a predictor for early detection of insulin resistance (IR) in patients with CHC infection. Research Design and Methods: Serum RBP4 was measured in 60 non diabetic CHC Patients classified according to Child- Pugh classification (Child A, Child B, Child C), 20 diabetic CHC patients and 20 age- and sex-matched healthy blood donors served as control subjects. RBP-4 correlation with the homeostasis model assessment of insulin resistance index (HOMA-IR) and metabolic factors was investigated.  Results: Serum RBP-4 levels were significantly lower in HCV infected patients and HCV diabetic patients compared with controls (HCV 16545.17± 10633.16, Diabetic HCV 10310 ± 4371.31, Control 27820.0 ± 9316.46, P< 0.001). In addition, serum levels of RBP-4 significantly decreased between all stages of cirrhosis, with the lowest level in Child C. HOMA-IR not significantly higher in HCV infected patients compared to control (HCV 5.54 ± 3.67, and Control 4.11 ± 2.42). RBP-4 levels correlate positively with GGT (P<0.01), CHOL (P<0.05) and TG (P<0.05) in HCV Child C, additionally, it shows significant positive correlation with TG (P< 0.05) in HCV Child B.  Conclusions: Disease severity may limit the role of RBP4 as a predictor of IR in CHC. These data demonstrate that RBP4 in CHC patients decreased due to reduced hepatic production, and it is not associated with insulin resistance. Keywords: HCV, RBP4, Insulin Resistance Abbreviations: RBP4: Retinol-binding protein 4, IR: insulin resistance, HOMA-IR: homeostasis model assessment of insulin resistance index, CHC: Chronic Hepatitis C Virus.

DOI

10.21608/ejhm.2013.15983

Authors

First Name

Wafaa Gh.

Last Name

Shousha

MiddleName

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Affiliation

Chemistry Department, Helwan University, Egypt

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First Name

OM Kolsoum

Last Name

El-Haddad

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Affiliation

Clinical Hepatology Department, Menofiya University, Egypt

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Orcid

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First Name

Ashraf A.

Last Name

Basuni

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Affiliation

Clinical Biochemistry Deparment, Menofiya University, Egypt

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Orcid

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First Name

Hatem A.

Last Name

El-Mezayen

MiddleName

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Affiliation

Chemistry Department, Helwan University, Egypt

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City

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Orcid

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First Name

Amany A.

Last Name

Abdalla

MiddleName

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Affiliation

Chemistry Department, Helwan University, Egypt

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Volume

51

Article Issue

1

Related Issue

3435

Issue Date

2013-04-01

Receive Date

2018-10-05

Publish Date

2013-04-01

Page Start

326

Page End

331

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_15983.html

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https://ejhm.journals.ekb.eg/service?article_code=15983

Order

15

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Association of A Novel Adipokine With Insulin Resistance And Disease Severity in HCV Infected Patients

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Article

Created At

22 Jan 2023