Abstract: The hazardous health effect of the exposure to 900-1800 MHz radiofrequency electromagnetic fields (RF-EMF) which emitted from mobile phones was investigated on the plasma protein and eye of newly born mice. Twenty one newly born mice were divided into 3 groups, the 1^st group served as control, the 2^nd group exposed to mobile phone radiation daily for one month (45 min/day) and the 3^rd group remained one month following the end of exposure. The results showed deleterious changes in the plasma protein pattern by electrophoretic analysis. Also, the microscopic examination demonstrated numerous histopathological and histochemical changes in the eye mainly represented by degenerated, hemorrhagic areas and detachment in some layers of the eye with alteration in collagen, polysaccharides, total protein and marked increase in amyloid beta (β) protein contents of newly born mice exposed to RF-EMF from mobile phone (45 min/day) for one month as well as after one month following the end of exposure. It was concluded that the exposure to mobile phone radiation causes plasma proteins alterations and eye pathology in newly born mice.