Abstract Introduction : The use of intraperitoneal (IP) chemotherapy as a treatment for ovarian cancer has been demonstrated to result in improved survival. Aim of the work: The aim of this work is to evaluate the applicability and efficacy of  fluoroscopic placed intraperitoneal port-A-cath  and to assess the  response rate to intraperitoneal chemotherapy in cases of  ovarian carcinoma . Methods: The studied group included ,22  female patients with malignant ovarian cancer whom referred from gynecological surgery and gynecological oncology units to the Vascular and  Interventional Radiology Unit, Ain Shams University Hospitals, for peritoneal port-A-cath  application. All the patients were known cases of either primary or recurrent ovarian cancer , underwent cytoreductive surgery and referred to us . Results:  Intraperitoneal port-A-cath with the aid of fluoroscopy showed highest technical success ( 91.9% ) and lowest complication rate on the long run compared to other methods of peritoneal access .  Patients with cancer ovary showed significant improvement of the disease process denoted by changes in the degree of ascites , peritoneal nodules and tumor marker level after receiving combined IV/ IP chemotherapy.   Conclusion: Port catheters proved to be the most safe method of long term access to the peritoneal cavity with the lowest complication rate compared to other methods of  access to the peritoneal cavity.