Background: Noise and crowdingare the most stressful factors for human beings. This study is aimed to clarify their effect on some thyroid hormones and the amelioration effect of sulprid . Material and Methods: Thirty six female rats were divided into four groups (6/each): 1-control, 2-treated with sulpiride drug, 3- rat exposed to noise (90db/3hper day for 45 days) 4-Noise plus drug, 5 – rat exposed to crowded exposure and 6- crowded plus drug. Results:  Noise and crowding stresses caused a significant increase only of T3 and T4 while there was a significant decrease in TSH. Sulpiride drug was ameliorated  these parameters.